Excessive activation of NMDA receptor inhibits the protective effect of endogenous bone marrow mesenchymal stem cells on promoting alveolarization in bronchopulmonary dysplasia

We studied the role of bone marrow mesenchymal stem cells (MSCs) in our established model of bronchopulmonary dysplasia (BPD) induced by intrauterine hypoxia in the rat. First, we found that intrauterine hypoxia can reduce the number of MSCs in lungs and bone marrow of rat neonates, whereas the admi...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2019-06, Vol.316 (6), p.C815-C827
Hauptverfasser:	Yue, Yinyan, Luo, Ziqiang, Liao, Zhengchang, Zhang, Liming, Liu, Shuai, Wang, Mingjie, Zhao, Feiyan, Cao, Chuanding, Ding, Ying, Yue, Shaojie
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Animals, Newborn Aspartic acid Bone dysplasia Bone marrow Bone Marrow Cells - metabolism Bronchopulmonary Dysplasia - metabolism Bronchopulmonary Dysplasia - pathology Bronchopulmonary Dysplasia - prevention & control Busulfan Cells, Cultured Colony-stimulating factor Cytoprotection - physiology Dizocilpine Female Fetal Hypoxia - complications Fetal Hypoxia - metabolism Fetal Hypoxia - pathology Glutamic acid receptors (ionotropic) Granulocyte colony-stimulating factor Hypoxia Leukocytes (granulocytic) Lung diseases Lungs Male Memantine Mesenchymal stem cells Mesenchymal Stem Cells - metabolism Mesenchyme N-Methyl-D-aspartic acid receptors Neonates Pregnancy Pulmonary Alveoli - growth & development Pulmonary Alveoli - metabolism Random Allocation Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - metabolism Respiratory function Stem cell transplantation Stem cells
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