Aspirin meets cGAS

Sensing of cytosolic DNA by cyclic GMP–AMP synthase (cGAS) is central to the pathogenesis of a number of autoinflammatory syndromes and possibly some autoimmune diseases, such as systemic lupus erythematosus (SLE). Activation of cGAS signalling requires its deacetylation, so might aspirin have thera...

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Veröffentlicht in:	Nature reviews. Rheumatology 2019-05, Vol.15 (5), p.254-255
1. Verfasser:	Elkon, Keith B.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/249/2510/2511 692/4023/1670/122/1613 692/700/565/1436 Acetates Acetylation Adenosine monophosphate AMP Anti-inflammatory agents Aspirin Autoimmune diseases Autoimmunity COX-2 inhibitors Cyclic GMP Cyclic guanosine monophosphate Deacetylation Deoxyribonucleic acid DNA Enzymes Genetic aspects Health aspects Lupus Lupus erythematosus Medicine Medicine & Public Health News & Views news-and-views Nitric oxide Nitrogen oxides Nucleotidyltransferases Rheumatology Salicylates Systemic lupus erythematosus Transferases
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Zusammenfassung:	Sensing of cytosolic DNA by cyclic GMP–AMP synthase (cGAS) is central to the pathogenesis of a number of autoinflammatory syndromes and possibly some autoimmune diseases, such as systemic lupus erythematosus (SLE). Activation of cGAS signalling requires its deacetylation, so might aspirin have therapeutic potential to treat SLE by acetylating cGAS?
ISSN:	1759-4790 1759-4804
DOI:	10.1038/s41584-019-0205-y