Iridium-Catalyzed Regioselective Synthesis of Trifluoromethylated Isocoumarins through Annulation of Benzoic Acids with Trifluoromethylated Alkynes

Iridium-Catalyzed Regioselective Synthesis of Trifluoromethylated Isocoumarins through Annulation of Benzoic Acids with Trifluoromethylated Alkynes

An unprecedented Ir-catalyzed oxidative coupling of benzoic acids with trifluoromethylated alkynes was successfully developed to provide diverse trifluoromethylated isocoumarins in moderate to good yields. This new practical procedure was highlighted by mild reaction conditions, broad substrate scop...

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Veröffentlicht in:Organic letters 2019-05, Vol.21 (9), p.3043-3047
Hauptverfasser: Liu, Guangyuan, Kuang, Guanghua, Zhang, Xingxing, Lu, Naihao, Fu, Yang, Peng, Yiyuan, Zhou, Yirong
Format: Artikel
Sprache:eng
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Zusammenfassung:An unprecedented Ir-catalyzed oxidative coupling of benzoic acids with trifluoromethylated alkynes was successfully developed to provide diverse trifluoromethylated isocoumarins in moderate to good yields. This new practical procedure was highlighted by mild reaction conditions, broad substrate scope, good regioselectivity, high efficiency, and easy operation.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.9b00572