Redox‐Neutral Decarbonylative Cross‐Couplings Coming of Age

Major progress has recently been made in the challenging redox‐neutral decarbonylative cross‐coupling of carboxylic acids. For example, the use of acid fluorides as effective cross‐coupling partners has been found to enable control of the decarbonylation selectivity and facilitates challenging Pd0‐catalyzed nucleophilic trifluoromethylation and exogenous base‐free Suzuki cross‐coupling reactions. In another recent advance, the use of acid chlorides in room temperature difluoromethylation and direct decarbonylative cross‐coupling of carboxylic acids allows these classical substrates to be used as aryl electrophiles in cross‐coupling reactions. Further challenges that are yet to be addressed in redox‐neutral decarbonylative cross‐couplings are also briefly summarized. Neutral selection: Major recent progress in the challenging redox‐neutral decarbonylative cross‐coupling of carboxylic acids is highlighted, including the use of acid fluorides as effective cross‐coupling partners to facilitate challenging Pd0‐catalyzed reactions and the use of acid chlorides in room temperature difluoromethylation and direct decarbonylative cross‐coupling reactions. Further challenges that are yet to be addressed are also briefly summarized.