Chronic inflammation is a key to inducing liver injury in blunt snout bream (Megalobrama amblycephala) fed with high-fat diet

The aim of this article is to investigate the mechanism of lipotoxicity induced by high-fat diets (HFD) in Megalobrama amblycephala. In the present study, fish (average initial weight 40.0 ± 0.35 g) were fed with two fat levels (6% and 11%) diets with four replicates for 60 days. At the end of the f...

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Veröffentlicht in:	Developmental and comparative immunology 2019-08, Vol.97, p.28-37
Hauptverfasser:	Dai, Yong-Jun, Cao, Xiu-Fei, Zhang, Ding-Dong, Li, Xiang-Fei, Liu, Wen-Bin, Jiang, Guang-Zhen
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Alanine transaminase Animals Antigens, CD - genetics Antigens, CD - metabolism Antigens, Differentiation, Myelomonocytic - genetics Antigens, Differentiation, Myelomonocytic - metabolism Antioxidants Apoptosis Apoptosis - drug effects Apoptosis - genetics Aspartate aminotransferase Bioassays Blood vessels Bream Caspase Caspase 3 - genetics Caspase 3 - metabolism Caspase 9 - genetics Caspase 9 - metabolism Caspase-3 Caspase-9 Cell cycle Chronic Disease Comet assay Cyprinidae - genetics Cyprinidae - metabolism Damage detection Deoxyribonucleic acid Diet Diet, High-Fat - adverse effects DNA DNA damage Enzymatic activity Erythrocytes Feeding Fish Fish Diseases - etiology Fish Diseases - genetics Fish Diseases - metabolism Gene expression Gene Expression - drug effects Genotoxicity High fat diet High-fat diets Inflammation Inflammation - complications Inflammation - genetics Inflammation - metabolism Liver Liver - drug effects Liver - metabolism Liver - pathology Liver Diseases - etiology Liver Diseases - genetics Liver Diseases - metabolism Liver injury Macrophages Megalobrama amblycephala Oxidative stress Proteins Survival Thioacetamide Thioacetamide - pharmacology
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Zusammenfassung:	The aim of this article is to investigate the mechanism of lipotoxicity induced by high-fat diets (HFD) in Megalobrama amblycephala. In the present study, fish (average initial weight 40.0 ± 0.35 g) were fed with two fat levels (6% and 11%) diets with four replicates for 60 days. At the end of the feeding trial, fish were challenged by thioacetamide (TAA) and survival rate was recorded for the next 96 h. The result showed that long-term HFD feeding induced a significant increase (P
ISSN:	0145-305X 1879-0089
DOI:	10.1016/j.dci.2019.03.009