Comments on GEDI vs. CVP goal-directed fluid resuscitation for COPD patients with septic shock: A randomized controlled trial

The software of PASS (power analysis and sample size) is used. [...]an enrollment of 130 patients would have a power of 80% (at a two-sided alpha level of 0.05) to detect a 30% increase of fluids volume in the GEDI-directed group, with allowance for a 10% loss to follow-up [3,4]. According to surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016 [6], norepinephrine is recommended for booster drugs. Dobutamine is recommended for patients with continuous low perfusion despite adequate fluid loading and vasoactive drugs are administered. [...]the author should list and compare the types and doses of all vasoactive drugs, not just the dose of norepinephrine.