Diverse immune responses to HBV surface epitope variants after vaccine booster in adolescents immunized in infancy

Diverse immune responses to HBV surface epitope variants after vaccine booster in adolescents immunized in infancy

We aimed to investigate immunity against hepatitis B surface antigen (HBsAg) mutants before and after boosters in adolescents who had lost antibodies against HBsAg (anti-HBs) despite neonatal vaccination. We recruited 142 participants from 15 to 21 years old who had received complete vaccination in...

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Veröffentlicht in:Clinical microbiology and infection 2019-09, Vol.25 (9), p.1140-1146
Hauptverfasser: Lai, M.-W., Liang, K.-H., Yeh, C.-T.
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Anamnestic response
antibody binding affinity
Cell Proliferation
Epitopes, T-Lymphocyte - genetics
Epitopes, T-Lymphocyte - immunology
Hepatitis B - immunology
Hepatitis B - prevention & control
Hepatitis B Antibodies - blood
Hepatitis B Surface Antigens - genetics
Hepatitis B Surface Antigens - immunology
Hepatitis B Vaccines - administration & dosage
Hepatitis B Vaccines - immunology
Hepatitis B virus - immunology
Humans
immune memory
Immunization, Secondary
Immunologic Memory
Interferon-gamma - metabolism
Interleukin-5 - metabolism
Mutation
T-cell epitopes
T-Lymphocytes - immunology
T-Lymphocytes - metabolism
Vaccination
vaccine-escape mutant
Young Adult
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Zusammenfassung:We aimed to investigate immunity against hepatitis B surface antigen (HBsAg) mutants before and after boosters in adolescents who had lost antibodies against HBsAg (anti-HBs) despite neonatal vaccination. We recruited 142 participants from 15 to 21 years old who had received complete vaccination in infancy but became anti-HBs-negative. Cellular immunity to HBsAg and T-cell epitope variants was assessed before and after boosters. Antibody affinity to variants was assessed after boosters. After one dose of booster, 12 out of 140 (8.6%) participants remained anti-HBs-negative. Anti-HBs titres were higher in those participants
ISSN:1198-743X
1469-0691
DOI:10.1016/j.cmi.2019.02.003