Single nucleotide polymorphisms of the CYP11B2, GNB3 and NOS3 genes in various ethnic groups of arctic zone of yakutia suffering from arterial hypertension

Introduction: This article presents the results of a study of the frequencies of single nucleotide polymorphisms of the CYP11B2 -344 T> C genes; GNB3 825 C> T; NOS3 -786 T> C and 894 G> T in different ethnic groups of residents of the Arctic zone of the republic "Sakha" (Yakutia), suffering from essential arterial hypertension. The aim: The aim of this study is to determine the presence of statistically significant differences in the frequencies of the above-mentioned polymorphisms in the studied ethnic groups of people living in the Arctic zone of Yakutia. Materials and methods: The material for the study was whole blood obtained during venipuncture. The volunteer groups studied were formed along ethnic lines and included the Yakuts, Slavs, Evens, and Evenks. Further, the representatives of the aforementioned ethnic groups were further grouped by aboriginal basis, in accordance with which the following groups were formed: "Indigenous Minorities of the Arctic Zone" and "Non-Indigenous Ethnic Groups of the Arctic Zone". To identify the polymorphisms indicated above, the method of real-time polymerase chain reaction with detection of the melting point of duplexes was used. Results: As a result, statistically significant (p ≤ 0.05) differences between the considered, in the framework of this study, ethnic groups at the points CYP11B2 -344 T> C; NOS3 -786 T> C and 894 G> T. Conclusions: The revealed differences can be further considered as a basis for studying the clinical features of the course of arterial hypertension in people with polymorphisms of the respective genes, as well as a basis for further pharmacogenetic studies.