The influence of rivaroxaban on markers of fibrinolysis and endothelial cell activation/injury in patients with venous thrombosis

•The effect of rivaroxaban on fibrinolysis and endothelial cells is poorly understood.•Rivaroxaban peak-, trough and baseline samples were analysed.•There was a reduced level of PAI-1 in rivaroxaban peak samples.•No other fibrinolytic markers or markers of endothelial activation was affected....

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Veröffentlicht in:	Thrombosis research 2019-05, Vol.177, p.154-156
Hauptverfasser:	Schultz, Nina Haagenrud, Holme, Pål Andre, Henriksson, Carola Elisabeth, Mowinckel, Marie-Christine, Sandset, Per Morten, Bratseth, Vibeke, Jacobsen, Eva-Marie
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Endothelial Cells - drug effects Factor Xa Inhibitors - therapeutic use Fibrinolysis - drug effects Humans Middle Aged Plasminogen Activator Inhibitor 1 - analysis Rivaroxaban - therapeutic use Venous Thrombosis - blood Venous Thrombosis - drug therapy
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Beschreibung
Zusammenfassung:	•The effect of rivaroxaban on fibrinolysis and endothelial cells is poorly understood.•Rivaroxaban peak-, trough and baseline samples were analysed.•There was a reduced level of PAI-1 in rivaroxaban peak samples.•No other fibrinolytic markers or markers of endothelial activation was affected.
ISSN:	0049-3848 1879-2472
DOI:	10.1016/j.thromres.2019.03.010