Emergence of colistin resistance during treatment of recurrent pneumonia caused by carbapenemase producing Klebsiella pneumoniae

Emergence of colistin resistance during treatment of recurrent pneumonia caused by carbapenemase producing Klebsiella pneumoniae

A 60-year-old woman received meropenem/colistin treatment for bilateral pneumonia caused by a ST15 carbapenemase producing Klebsiella pneumoniae. The patient recovered but re-infection with the same (ST15), but now colistin-resistant K. pneumoniae, occurred. The molecular mechanism of the emerged co...

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Veröffentlicht in:Diagnostic microbiology and infectious disease 2019-08, Vol.94 (4), p.407-409
Hauptverfasser: Matheeussen, Veerle, Xavier, Basil Britto, Mermans, Ingrid, De Weerdt, Annick, Lammens, Christine, Goossens, Herman, Jansens, Hilde, Malhotra-Kumar, Surbhi
Format: Artikel
Sprache:eng
Schlagworte:
Carbapenemase producing Enterobactericeae
Colistin resistance
K. pneumoniae
ST15
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Zusammenfassung:A 60-year-old woman received meropenem/colistin treatment for bilateral pneumonia caused by a ST15 carbapenemase producing Klebsiella pneumoniae. The patient recovered but re-infection with the same (ST15), but now colistin-resistant K. pneumoniae, occurred. The molecular mechanism of the emerged colistin resistance was identified as mgrB gene modification by insertion element (IS) IS903B.
ISSN:0732-8893
1879-0070
DOI:10.1016/j.diagmicrobio.2019.02.014