Dietary trans and saturated fatty acids effects on semen quality, hormonal levels and expression of genes related to steroid metabolism in mouse adipose tissue
Our objectives were to assess sperm alteration and adipose tissue (AT) genes expression related to steroid metabolism subsequent to fatty acids consumption. Twenty‐nine mature male mice were divided into: fat diet (FD; n = 15) and the control group (n = 14). FD group was fed with low level of trans...
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| Veröffentlicht in: | Andrologia 2019-06, Vol.51 (5), p.e13259-n/a |
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| creator | Molaie, Solmaz Shahverdi, Abdolhossein Sharafi, Mohsen Shahhoseini, Maryam Rashki Ghaleno, Leila Esmaeili, Vahid Abed‐Heydari, Elham Numan Bucak, Mustafa Alizadeh, AliReza |
| description | Our objectives were to assess sperm alteration and adipose tissue (AT) genes expression related to steroid metabolism subsequent to fatty acids consumption. Twenty‐nine mature male mice were divided into: fat diet (FD; n = 15) and the control group (n = 14). FD group was fed with low level of trans and saturated fatty acids source for 60 days. Sperm parameters, levels of hormones and the mRNA abundance of the target genes in AT were assessed. The sperm concentration, total and progressive motilities were lower in FD group compared to that of control (p |
| doi_str_mv | 10.1111/and.13259 |
| format | Article |
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Twenty‐nine mature male mice were divided into: fat diet (FD; n = 15) and the control group (n = 14). FD group was fed with low level of trans and saturated fatty acids source for 60 days. Sperm parameters, levels of hormones and the mRNA abundance of the target genes in AT were assessed. The sperm concentration, total and progressive motilities were lower in FD group compared to that of control (p < 0.01). Blood estradiol levels increased in FD (p < 0.001), whereas no significant difference was observed in testosterone. The mRNA levels of StAR, CYP11A1, CYP17A1, 17βHSD7 and 17βHSD12 in AT of FD were higher than those of the control (p < 0.05). In contrast, mRNA level of Cyp19a1 in FD was significantly (p < 0.05) lower than that of control. 17βHSD12 and 17βHSD7 (as oestrogenic genes) increased, while 17βHSD5 and 17βHSD3 (as androgenic genes) remained unchanged, indicating that dietary trans/saturated fatty acids affect AT genes expression. Probably, sperm parameters were altered by increment of expression level of genes involved in oestrogenic metabolism rather than those engaged in androgenic metabolism after fatty acids consumption.</description><identifier>ISSN: 0303-4569</identifier><identifier>EISSN: 1439-0272</identifier><identifier>DOI: 10.1111/and.13259</identifier><identifier>PMID: 30873638</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>17β-Estradiol ; Adipose tissue ; Adipose Tissue - metabolism ; Androgens - blood ; Androgens - metabolism ; Animals ; Diet, High-Fat - adverse effects ; Dietary Fats - adverse effects ; dietary fatty acids ; Estrogens - blood ; Estrogens - metabolism ; Fatty acids ; Fatty Acids - adverse effects ; Male ; Metabolism ; Mice ; Models, Animal ; mRNA ; Semen ; semen quality ; Sperm ; Sperm Count ; steroidogenic enzyme gene expression ; Steroids - metabolism ; Testosterone</subject><ispartof>Andrologia, 2019-06, Vol.51 (5), p.e13259-n/a</ispartof><rights>2019 Blackwell Verlag GmbH</rights><rights>2019 Blackwell Verlag GmbH.</rights><rights>Copyright © 2019 Blackwell Verlag GmbH</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3889-c0c763cb67a809d5acb7d8032f5939ab98d99643613904ee4ea442eeeaa4d6b93</citedby><cites>FETCH-LOGICAL-c3889-c0c763cb67a809d5acb7d8032f5939ab98d99643613904ee4ea442eeeaa4d6b93</cites><orcidid>0000-0001-7273-9793</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fand.13259$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fand.13259$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30873638$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Molaie, Solmaz</creatorcontrib><creatorcontrib>Shahverdi, Abdolhossein</creatorcontrib><creatorcontrib>Sharafi, Mohsen</creatorcontrib><creatorcontrib>Shahhoseini, Maryam</creatorcontrib><creatorcontrib>Rashki Ghaleno, Leila</creatorcontrib><creatorcontrib>Esmaeili, Vahid</creatorcontrib><creatorcontrib>Abed‐Heydari, Elham</creatorcontrib><creatorcontrib>Numan Bucak, Mustafa</creatorcontrib><creatorcontrib>Alizadeh, AliReza</creatorcontrib><title>Dietary trans and saturated fatty acids effects on semen quality, hormonal levels and expression of genes related to steroid metabolism in mouse adipose tissue</title><title>Andrologia</title><addtitle>Andrologia</addtitle><description>Our objectives were to assess sperm alteration and adipose tissue (AT) genes expression related to steroid metabolism subsequent to fatty acids consumption. Twenty‐nine mature male mice were divided into: fat diet (FD; n = 15) and the control group (n = 14). FD group was fed with low level of trans and saturated fatty acids source for 60 days. Sperm parameters, levels of hormones and the mRNA abundance of the target genes in AT were assessed. The sperm concentration, total and progressive motilities were lower in FD group compared to that of control (p < 0.01). Blood estradiol levels increased in FD (p < 0.001), whereas no significant difference was observed in testosterone. The mRNA levels of StAR, CYP11A1, CYP17A1, 17βHSD7 and 17βHSD12 in AT of FD were higher than those of the control (p < 0.05). In contrast, mRNA level of Cyp19a1 in FD was significantly (p < 0.05) lower than that of control. 17βHSD12 and 17βHSD7 (as oestrogenic genes) increased, while 17βHSD5 and 17βHSD3 (as androgenic genes) remained unchanged, indicating that dietary trans/saturated fatty acids affect AT genes expression. Probably, sperm parameters were altered by increment of expression level of genes involved in oestrogenic metabolism rather than those engaged in androgenic metabolism after fatty acids consumption.</description><subject>17β-Estradiol</subject><subject>Adipose tissue</subject><subject>Adipose Tissue - metabolism</subject><subject>Androgens - blood</subject><subject>Androgens - metabolism</subject><subject>Animals</subject><subject>Diet, High-Fat - adverse effects</subject><subject>Dietary Fats - adverse effects</subject><subject>dietary fatty acids</subject><subject>Estrogens - blood</subject><subject>Estrogens - metabolism</subject><subject>Fatty acids</subject><subject>Fatty Acids - adverse effects</subject><subject>Male</subject><subject>Metabolism</subject><subject>Mice</subject><subject>Models, Animal</subject><subject>mRNA</subject><subject>Semen</subject><subject>semen quality</subject><subject>Sperm</subject><subject>Sperm Count</subject><subject>steroidogenic enzyme gene expression</subject><subject>Steroids - metabolism</subject><subject>Testosterone</subject><issn>0303-4569</issn><issn>1439-0272</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcFu1TAQRS0Eok-lC34AWWIDUtPasWPHy6qlgFTBBtaRY0_AlRO_ehzgfQ2_imkKCyRmM5ujM6N7CXnO2Rmvc24Xf8ZF25lHZMelMA1rdfuY7JhgopGdMkfkBPGW1ZGd1lI-JUeC9Voo0e_Iz6sAxeYDLdkuSKuMoi1rtgU8nWwpB2pd8EhhmsAVpGmhCDMs9G61MZTDKf2a8pwWG2mEbxA3B_zYZ0AMlU4T_QILIM0Q760lUSyQU_B0rrfHFAPONCx0TisCtT7sU90lIK7wjDyZbEQ4edjH5PP1m0-X75qbj2_fX17cNE70vWkcc1oJNypte2Z8Z92ofc9EO3VGGDua3hujpFBcGCYBJFgpWwCwVno1GnFMXm3efU53K2AZ5oAOYrQL1LeGlhvBVS86VdGX_6C3ac01gEq1XBvFNGeVer1RLifEDNOwz2GuSQ-cDb-LG2pOw31xlX3xYFzHGfxf8k9NFTjfgO8hwuH_puHiw9Wm_AWeDaR1</recordid><startdate>201906</startdate><enddate>201906</enddate><creator>Molaie, Solmaz</creator><creator>Shahverdi, Abdolhossein</creator><creator>Sharafi, Mohsen</creator><creator>Shahhoseini, Maryam</creator><creator>Rashki Ghaleno, Leila</creator><creator>Esmaeili, Vahid</creator><creator>Abed‐Heydari, Elham</creator><creator>Numan Bucak, Mustafa</creator><creator>Alizadeh, AliReza</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7273-9793</orcidid></search><sort><creationdate>201906</creationdate><title>Dietary trans and saturated fatty acids effects on semen quality, hormonal levels and expression of genes related to steroid metabolism in mouse adipose tissue</title><author>Molaie, Solmaz ; Shahverdi, Abdolhossein ; Sharafi, Mohsen ; Shahhoseini, Maryam ; Rashki Ghaleno, Leila ; Esmaeili, Vahid ; Abed‐Heydari, Elham ; Numan Bucak, Mustafa ; Alizadeh, AliReza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3889-c0c763cb67a809d5acb7d8032f5939ab98d99643613904ee4ea442eeeaa4d6b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>17β-Estradiol</topic><topic>Adipose tissue</topic><topic>Adipose Tissue - metabolism</topic><topic>Androgens - blood</topic><topic>Androgens - metabolism</topic><topic>Animals</topic><topic>Diet, High-Fat - adverse effects</topic><topic>Dietary Fats - adverse effects</topic><topic>dietary fatty acids</topic><topic>Estrogens - blood</topic><topic>Estrogens - metabolism</topic><topic>Fatty acids</topic><topic>Fatty Acids - adverse effects</topic><topic>Male</topic><topic>Metabolism</topic><topic>Mice</topic><topic>Models, Animal</topic><topic>mRNA</topic><topic>Semen</topic><topic>semen quality</topic><topic>Sperm</topic><topic>Sperm Count</topic><topic>steroidogenic enzyme gene expression</topic><topic>Steroids - metabolism</topic><topic>Testosterone</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Molaie, Solmaz</creatorcontrib><creatorcontrib>Shahverdi, Abdolhossein</creatorcontrib><creatorcontrib>Sharafi, Mohsen</creatorcontrib><creatorcontrib>Shahhoseini, Maryam</creatorcontrib><creatorcontrib>Rashki Ghaleno, Leila</creatorcontrib><creatorcontrib>Esmaeili, Vahid</creatorcontrib><creatorcontrib>Abed‐Heydari, Elham</creatorcontrib><creatorcontrib>Numan Bucak, Mustafa</creatorcontrib><creatorcontrib>Alizadeh, AliReza</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Andrologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Molaie, Solmaz</au><au>Shahverdi, Abdolhossein</au><au>Sharafi, Mohsen</au><au>Shahhoseini, Maryam</au><au>Rashki Ghaleno, Leila</au><au>Esmaeili, Vahid</au><au>Abed‐Heydari, Elham</au><au>Numan Bucak, Mustafa</au><au>Alizadeh, AliReza</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary trans and saturated fatty acids effects on semen quality, hormonal levels and expression of genes related to steroid metabolism in mouse adipose tissue</atitle><jtitle>Andrologia</jtitle><addtitle>Andrologia</addtitle><date>2019-06</date><risdate>2019</risdate><volume>51</volume><issue>5</issue><spage>e13259</spage><epage>n/a</epage><pages>e13259-n/a</pages><issn>0303-4569</issn><eissn>1439-0272</eissn><abstract>Our objectives were to assess sperm alteration and adipose tissue (AT) genes expression related to steroid metabolism subsequent to fatty acids consumption. Twenty‐nine mature male mice were divided into: fat diet (FD; n = 15) and the control group (n = 14). FD group was fed with low level of trans and saturated fatty acids source for 60 days. Sperm parameters, levels of hormones and the mRNA abundance of the target genes in AT were assessed. The sperm concentration, total and progressive motilities were lower in FD group compared to that of control (p < 0.01). Blood estradiol levels increased in FD (p < 0.001), whereas no significant difference was observed in testosterone. The mRNA levels of StAR, CYP11A1, CYP17A1, 17βHSD7 and 17βHSD12 in AT of FD were higher than those of the control (p < 0.05). In contrast, mRNA level of Cyp19a1 in FD was significantly (p < 0.05) lower than that of control. 17βHSD12 and 17βHSD7 (as oestrogenic genes) increased, while 17βHSD5 and 17βHSD3 (as androgenic genes) remained unchanged, indicating that dietary trans/saturated fatty acids affect AT genes expression. Probably, sperm parameters were altered by increment of expression level of genes involved in oestrogenic metabolism rather than those engaged in androgenic metabolism after fatty acids consumption.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30873638</pmid><doi>10.1111/and.13259</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-7273-9793</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 17β-Estradiol Adipose tissue Adipose Tissue - metabolism Androgens - blood Androgens - metabolism Animals Diet, High-Fat - adverse effects Dietary Fats - adverse effects dietary fatty acids Estrogens - blood Estrogens - metabolism Fatty acids Fatty Acids - adverse effects Male Metabolism Mice Models, Animal mRNA Semen semen quality Sperm Sperm Count steroidogenic enzyme gene expression Steroids - metabolism Testosterone |
| title | Dietary trans and saturated fatty acids effects on semen quality, hormonal levels and expression of genes related to steroid metabolism in mouse adipose tissue |
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