An evaluation of the epidemiology, management and outcomes for perforated peptic ulcers across the North of England over 15 years: A retrospective cohort study

The management of perforated peptic ulcers has evolved over time and includes laparoscopic or open repair, and conservative management. The utilisation of, and outcomes from these strategies are not clear. Trends in epidemiology, management and outcomes for perforated peptic ulcer across the North of England over a 15-year period were analyzed. Emergency General Surgical admissions data from nine NHS trusts in the North of England from 2002 to 2016 were collected and analyzed, including demographics, interventions and outcomes. Cases were identified using ICD-10 codes K25, K26 and K27 0.1, 0.2, 0.5, 0.6. Peptic ulcer perforation accounted for 2373 of 491141 admissions (0.48%), with a decreased incidence over time (0.62% in 2002–2006 to 0.36% in 2012–2016). Over the 15 years studied, an increasing proportion of cases were managed laparoscopically (4.5%–18.4%, p