The influence of low dose Bisphenol A on whole genome DNA methylation and chromatin compaction in different human cell lines

The influence of low dose Bisphenol A on whole genome DNA methylation and chromatin compaction in different human cell lines

•DNA methylation and chromatin compaction oscillate non-monotonously depending on BPA exposure conditions.•Dose-response curves depend on cell type and can be described by the fourth degree polynomial regression functions.•There is exist more or less strong inverse correlation across cell types betw...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Toxicology in vitro 2019-08, Vol.58, p.26-34
Hauptverfasser: Suchkova, I.O., Sasina, L.K., Dergacheva, N.I., Sofronov, G.A., Patkin, E.L.
Format: Artikel
Sprache:eng
Schlagworte:
Bisphenol A
Cell lines
Chromatin
Deoxyribonucleic acid
DNA
DNA methylation
Genomes
Phenols
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 34
container_issue
container_start_page 26
container_title Toxicology in vitro
container_volume 58
creator Suchkova, I.O.
Sasina, L.K.
Dergacheva, N.I.
Sofronov, G.A.
Patkin, E.L.
description •DNA methylation and chromatin compaction oscillate non-monotonously depending on BPA exposure conditions.•Dose-response curves depend on cell type and can be described by the fourth degree polynomial regression functions.•There is exist more or less strong inverse correlation across cell types between DNA methylation and chromatin accessibility.
doi_str_mv 10.1016/j.tiv.2019.03.010
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2193163554</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0887233318303503</els_id><sourcerecordid>2193163554</sourcerecordid><originalsourceid>FETCH-LOGICAL-c381t-ea9f6969d4266a5d2c707bb7ab518e77d79fbc31f00778efefb6bc59d073c7ac3</originalsourceid><addsrcrecordid>eNp9kU2PFCEQhonRuLOrP8CLIfHipVtopqGJp3FdP5KNXtYzoaGwmdAwQvduNvHHyzirBw-eSPE-VanUg9ALSlpKKH-zbxd_23aEypawllDyCG3oIGTDqBCP0YYMg2g6xtgZOi9lTwjph448RWeMDILXcIN-3kyAfXRhhWgAJ4dDusM2FcDvfDlMEFPAO5wivptSAPy9fsyA33_Z4RmW6T7oxddQR4vNlNNcy4hNmg_a_A5qZb1zkCEueFpnXVMIAQcfoTxDT5wOBZ4_vBfo24erm8tPzfXXj58vd9eNYQNdGtDSccml3Xac6952RhAxjkKPPR1ACCukGw2jjhAhBnDgRj6aXloimBHasAv0-jT3kNOPFcqiZl-Oa-gIaS2qo5JRzvp-W9FX_6D7tOZYt1Nd11Mu5bYTlaInyuRUSganDtnPOt8rStRRjdqrqkYd1SjCVFVTe14-TF7HGezfjj8uKvD2BEA9xa2HrIrxRyvWZzCLssn_Z_wvQMOf8A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2251699427</pqid></control><display><type>article</type><title>The influence of low dose Bisphenol A on whole genome DNA methylation and chromatin compaction in different human cell lines</title><source>Access via ScienceDirect (Elsevier)</source><creator>Suchkova, I.O. ; Sasina, L.K. ; Dergacheva, N.I. ; Sofronov, G.A. ; Patkin, E.L.</creator><creatorcontrib>Suchkova, I.O. ; Sasina, L.K. ; Dergacheva, N.I. ; Sofronov, G.A. ; Patkin, E.L.</creatorcontrib><description>•DNA methylation and chromatin compaction oscillate non-monotonously depending on BPA exposure conditions.•Dose-response curves depend on cell type and can be described by the fourth degree polynomial regression functions.•There is exist more or less strong inverse correlation across cell types between DNA methylation and chromatin accessibility.</description><identifier>ISSN: 0887-2333</identifier><identifier>EISSN: 1879-3177</identifier><identifier>DOI: 10.1016/j.tiv.2019.03.010</identifier><identifier>PMID: 30876887</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Bisphenol A ; Cell lines ; Chromatin ; Deoxyribonucleic acid ; DNA ; DNA methylation ; Genomes ; Phenols</subject><ispartof>Toxicology in vitro, 2019-08, Vol.58, p.26-34</ispartof><rights>2019 Elsevier Ltd</rights><rights>Copyright Elsevier Science Ltd. Aug 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-ea9f6969d4266a5d2c707bb7ab518e77d79fbc31f00778efefb6bc59d073c7ac3</citedby><cites>FETCH-LOGICAL-c381t-ea9f6969d4266a5d2c707bb7ab518e77d79fbc31f00778efefb6bc59d073c7ac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.tiv.2019.03.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30876887$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Suchkova, I.O.</creatorcontrib><creatorcontrib>Sasina, L.K.</creatorcontrib><creatorcontrib>Dergacheva, N.I.</creatorcontrib><creatorcontrib>Sofronov, G.A.</creatorcontrib><creatorcontrib>Patkin, E.L.</creatorcontrib><title>The influence of low dose Bisphenol A on whole genome DNA methylation and chromatin compaction in different human cell lines</title><title>Toxicology in vitro</title><addtitle>Toxicol In Vitro</addtitle><description>•DNA methylation and chromatin compaction oscillate non-monotonously depending on BPA exposure conditions.•Dose-response curves depend on cell type and can be described by the fourth degree polynomial regression functions.•There is exist more or less strong inverse correlation across cell types between DNA methylation and chromatin accessibility.</description><subject>Bisphenol A</subject><subject>Cell lines</subject><subject>Chromatin</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA methylation</subject><subject>Genomes</subject><subject>Phenols</subject><issn>0887-2333</issn><issn>1879-3177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kU2PFCEQhonRuLOrP8CLIfHipVtopqGJp3FdP5KNXtYzoaGwmdAwQvduNvHHyzirBw-eSPE-VanUg9ALSlpKKH-zbxd_23aEypawllDyCG3oIGTDqBCP0YYMg2g6xtgZOi9lTwjph448RWeMDILXcIN-3kyAfXRhhWgAJ4dDusM2FcDvfDlMEFPAO5wivptSAPy9fsyA33_Z4RmW6T7oxddQR4vNlNNcy4hNmg_a_A5qZb1zkCEueFpnXVMIAQcfoTxDT5wOBZ4_vBfo24erm8tPzfXXj58vd9eNYQNdGtDSccml3Xac6952RhAxjkKPPR1ACCukGw2jjhAhBnDgRj6aXloimBHasAv0-jT3kNOPFcqiZl-Oa-gIaS2qo5JRzvp-W9FX_6D7tOZYt1Nd11Mu5bYTlaInyuRUSganDtnPOt8rStRRjdqrqkYd1SjCVFVTe14-TF7HGezfjj8uKvD2BEA9xa2HrIrxRyvWZzCLssn_Z_wvQMOf8A</recordid><startdate>20190801</startdate><enddate>20190801</enddate><creator>Suchkova, I.O.</creator><creator>Sasina, L.K.</creator><creator>Dergacheva, N.I.</creator><creator>Sofronov, G.A.</creator><creator>Patkin, E.L.</creator><general>Elsevier Ltd</general><general>Elsevier Science Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20190801</creationdate><title>The influence of low dose Bisphenol A on whole genome DNA methylation and chromatin compaction in different human cell lines</title><author>Suchkova, I.O. ; Sasina, L.K. ; Dergacheva, N.I. ; Sofronov, G.A. ; Patkin, E.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-ea9f6969d4266a5d2c707bb7ab518e77d79fbc31f00778efefb6bc59d073c7ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Bisphenol A</topic><topic>Cell lines</topic><topic>Chromatin</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA methylation</topic><topic>Genomes</topic><topic>Phenols</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suchkova, I.O.</creatorcontrib><creatorcontrib>Sasina, L.K.</creatorcontrib><creatorcontrib>Dergacheva, N.I.</creatorcontrib><creatorcontrib>Sofronov, G.A.</creatorcontrib><creatorcontrib>Patkin, E.L.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Toxicology in vitro</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suchkova, I.O.</au><au>Sasina, L.K.</au><au>Dergacheva, N.I.</au><au>Sofronov, G.A.</au><au>Patkin, E.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The influence of low dose Bisphenol A on whole genome DNA methylation and chromatin compaction in different human cell lines</atitle><jtitle>Toxicology in vitro</jtitle><addtitle>Toxicol In Vitro</addtitle><date>2019-08-01</date><risdate>2019</risdate><volume>58</volume><spage>26</spage><epage>34</epage><pages>26-34</pages><issn>0887-2333</issn><eissn>1879-3177</eissn><abstract>•DNA methylation and chromatin compaction oscillate non-monotonously depending on BPA exposure conditions.•Dose-response curves depend on cell type and can be described by the fourth degree polynomial regression functions.•There is exist more or less strong inverse correlation across cell types between DNA methylation and chromatin accessibility.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>30876887</pmid><doi>10.1016/j.tiv.2019.03.010</doi><tpages>9</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0887-2333
ispartof Toxicology in vitro, 2019-08, Vol.58, p.26-34
issn 0887-2333
1879-3177
language eng
recordid cdi_proquest_miscellaneous_2193163554
source Access via ScienceDirect (Elsevier)
subjects Bisphenol A
Cell lines
Chromatin
Deoxyribonucleic acid
DNA
DNA methylation
Genomes
Phenols
title The influence of low dose Bisphenol A on whole genome DNA methylation and chromatin compaction in different human cell lines
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-04T05%3A58%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20influence%20of%20low%20dose%20Bisphenol%20A%20on%20whole%20genome%20DNA%20methylation%20and%20chromatin%20compaction%20in%20different%20human%20cell%20lines&rft.jtitle=Toxicology%20in%20vitro&rft.au=Suchkova,%20I.O.&rft.date=2019-08-01&rft.volume=58&rft.spage=26&rft.epage=34&rft.pages=26-34&rft.issn=0887-2333&rft.eissn=1879-3177&rft_id=info:doi/10.1016/j.tiv.2019.03.010&rft_dat=%3Cproquest_cross%3E2193163554%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2251699427&rft_id=info:pmid/30876887&rft_els_id=S0887233318303503&rfr_iscdi=true