The influence of low dose Bisphenol A on whole genome DNA methylation and chromatin compaction in different human cell lines

The influence of low dose Bisphenol A on whole genome DNA methylation and chromatin compaction in different human cell lines

•DNA methylation and chromatin compaction oscillate non-monotonously depending on BPA exposure conditions.•Dose-response curves depend on cell type and can be described by the fourth degree polynomial regression functions.•There is exist more or less strong inverse correlation across cell types betw...

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Veröffentlicht in:Toxicology in vitro 2019-08, Vol.58, p.26-34
Hauptverfasser: Suchkova, I.O., Sasina, L.K., Dergacheva, N.I., Sofronov, G.A., Patkin, E.L.
Format: Artikel
Sprache:eng
Schlagworte:
Bisphenol A
Cell lines
Chromatin
Deoxyribonucleic acid
DNA
DNA methylation
Genomes
Phenols
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Beschreibung
Zusammenfassung:•DNA methylation and chromatin compaction oscillate non-monotonously depending on BPA exposure conditions.•Dose-response curves depend on cell type and can be described by the fourth degree polynomial regression functions.•There is exist more or less strong inverse correlation across cell types between DNA methylation and chromatin accessibility.
ISSN:0887-2333
1879-3177
DOI:10.1016/j.tiv.2019.03.010