Comparison of initial treatment with and without corticosteroids for suspected acute pancreatitis in dogs
Objectives To compare initial treatment with and without corticosteroids for acute pancreatitis in dogs and investigate the therapeutic efficacy and prognosis. Materials and Methods Sixty‐five dogs were included in this non‐blinded, non‐randomised clinical study. Dogs with acute pancreatitis receive...
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| Veröffentlicht in: | Journal of small animal practice 2019-05, Vol.60 (5), p.298-304 |
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| container_title | Journal of small animal practice |
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| creator | Okanishi, H. Nagata, T. Nakane, S. Watari, T. |
| description | Objectives
To compare initial treatment with and without corticosteroids for acute pancreatitis in dogs and investigate the therapeutic efficacy and prognosis.
Materials and Methods
Sixty‐five dogs were included in this non‐blinded, non‐randomised clinical study. Dogs with acute pancreatitis received treatment either with dose of 1 mg/kg/day prednisolone (n=45) or without prednisolone (n=20). Response to treatment was based on changes in the C‐reactive protein concentration, improvement in clinical signs, duration of hospitalisation, mortality and recurrence rate.
Results
From the third day of hospitalisation, C‐reactive protein concentration was significantly lower in the prednisolone group than that in the non‐prednisolone group. The number of days required to reach a C‐reactive protein concentration of |
| doi_str_mv | 10.1111/jsap.12994 |
| format | Article |
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To compare initial treatment with and without corticosteroids for acute pancreatitis in dogs and investigate the therapeutic efficacy and prognosis.
Materials and Methods
Sixty‐five dogs were included in this non‐blinded, non‐randomised clinical study. Dogs with acute pancreatitis received treatment either with dose of 1 mg/kg/day prednisolone (n=45) or without prednisolone (n=20). Response to treatment was based on changes in the C‐reactive protein concentration, improvement in clinical signs, duration of hospitalisation, mortality and recurrence rate.
Results
From the third day of hospitalisation, C‐reactive protein concentration was significantly lower in the prednisolone group than that in the non‐prednisolone group. The number of days required to reach a C‐reactive protein concentration of <2 mg/dL and clinical score of ≤2 was significantly lower in the prednisolone group. The mortality rate 1 month after discharge was significantly lower in the prednisolone group (11.3% versus 46.1%).
Clinical Significance
In dogs with acute pancreatitis, initial treatment with prednisolone resulted in earlier reductions in C‐reactive protein concentration and earlier improvement of clinical signs.</description><identifier>ISSN: 0022-4510</identifier><identifier>EISSN: 1748-5827</identifier><identifier>DOI: 10.1111/jsap.12994</identifier><identifier>PMID: 30868606</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Acute Disease ; Adrenal Cortex Hormones ; Animals ; C-Reactive Protein - analysis ; Corticoids ; Corticosteroids ; Dog Diseases ; Dogs ; Mortality ; Pancreatitis ; Pancreatitis - veterinary ; Prednisolone ; Proteins</subject><ispartof>Journal of small animal practice, 2019-05, Vol.60 (5), p.298-304</ispartof><rights>2019 British Small Animal Veterinary Association</rights><rights>2019 British Small Animal Veterinary Association.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3574-f506a703cc69e66c77f8e54a0c3485931049769db8ca34b7fca2ca9144ac952a3</citedby><cites>FETCH-LOGICAL-c3574-f506a703cc69e66c77f8e54a0c3485931049769db8ca34b7fca2ca9144ac952a3</cites><orcidid>0000-0002-7076-3682</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjsap.12994$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjsap.12994$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30868606$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Okanishi, H.</creatorcontrib><creatorcontrib>Nagata, T.</creatorcontrib><creatorcontrib>Nakane, S.</creatorcontrib><creatorcontrib>Watari, T.</creatorcontrib><title>Comparison of initial treatment with and without corticosteroids for suspected acute pancreatitis in dogs</title><title>Journal of small animal practice</title><addtitle>J Small Anim Pract</addtitle><description>Objectives
To compare initial treatment with and without corticosteroids for acute pancreatitis in dogs and investigate the therapeutic efficacy and prognosis.
Materials and Methods
Sixty‐five dogs were included in this non‐blinded, non‐randomised clinical study. Dogs with acute pancreatitis received treatment either with dose of 1 mg/kg/day prednisolone (n=45) or without prednisolone (n=20). Response to treatment was based on changes in the C‐reactive protein concentration, improvement in clinical signs, duration of hospitalisation, mortality and recurrence rate.
Results
From the third day of hospitalisation, C‐reactive protein concentration was significantly lower in the prednisolone group than that in the non‐prednisolone group. The number of days required to reach a C‐reactive protein concentration of <2 mg/dL and clinical score of ≤2 was significantly lower in the prednisolone group. The mortality rate 1 month after discharge was significantly lower in the prednisolone group (11.3% versus 46.1%).
Clinical Significance
In dogs with acute pancreatitis, initial treatment with prednisolone resulted in earlier reductions in C‐reactive protein concentration and earlier improvement of clinical signs.</description><subject>Acute Disease</subject><subject>Adrenal Cortex Hormones</subject><subject>Animals</subject><subject>C-Reactive Protein - analysis</subject><subject>Corticoids</subject><subject>Corticosteroids</subject><subject>Dog Diseases</subject><subject>Dogs</subject><subject>Mortality</subject><subject>Pancreatitis</subject><subject>Pancreatitis - veterinary</subject><subject>Prednisolone</subject><subject>Proteins</subject><issn>0022-4510</issn><issn>1748-5827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1LJDEQhoOs6OjuxR8ggb2I0Jqk89E5yuCuirAL7p5DTTq9m6G70yZpZP69GUc9eLAuVQUPD0W9CJ1QckFLXa4TTBeUac330IIq3lSiYeoLWhDCWMUFJYfoKKV1WSVX5AAd1qSRjSRygfwyDBNEn8KIQ4f96LOHHufoIA9uzPjJ5_8YxvZlCHPGNsTsbUjZxeDbhLsQcZrT5Gx2LQY7Z4cnGO3WUGSpOHEb_qWvaL-DPrlvr_0Y_f1x_Wd5U93_-nm7vLqvbC0UrzpBJChSWyu1k9Iq1TVOcCC25o3QNSVcK6nbVWOh5ivVWWAWNOUcrBYM6mN0tvNOMTzOLmUz-GRd38PowpwMo5rWQmjKCvr9A7oOcxzLdYYxKhhtiKCFOt9RNoaUouvMFP0AcWMoMdsAzDYA8xJAgU9flfNqcO07-vbxAtAd8OR7t_lEZe4ern7vpM-fBZGV</recordid><startdate>201905</startdate><enddate>201905</enddate><creator>Okanishi, H.</creator><creator>Nagata, T.</creator><creator>Nakane, S.</creator><creator>Watari, T.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7076-3682</orcidid></search><sort><creationdate>201905</creationdate><title>Comparison of initial treatment with and without corticosteroids for suspected acute pancreatitis in dogs</title><author>Okanishi, H. ; Nagata, T. ; Nakane, S. ; Watari, T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3574-f506a703cc69e66c77f8e54a0c3485931049769db8ca34b7fca2ca9144ac952a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acute Disease</topic><topic>Adrenal Cortex Hormones</topic><topic>Animals</topic><topic>C-Reactive Protein - analysis</topic><topic>Corticoids</topic><topic>Corticosteroids</topic><topic>Dog Diseases</topic><topic>Dogs</topic><topic>Mortality</topic><topic>Pancreatitis</topic><topic>Pancreatitis - veterinary</topic><topic>Prednisolone</topic><topic>Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Okanishi, H.</creatorcontrib><creatorcontrib>Nagata, T.</creatorcontrib><creatorcontrib>Nakane, S.</creatorcontrib><creatorcontrib>Watari, T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of small animal practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Okanishi, H.</au><au>Nagata, T.</au><au>Nakane, S.</au><au>Watari, T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of initial treatment with and without corticosteroids for suspected acute pancreatitis in dogs</atitle><jtitle>Journal of small animal practice</jtitle><addtitle>J Small Anim Pract</addtitle><date>2019-05</date><risdate>2019</risdate><volume>60</volume><issue>5</issue><spage>298</spage><epage>304</epage><pages>298-304</pages><issn>0022-4510</issn><eissn>1748-5827</eissn><abstract>Objectives
To compare initial treatment with and without corticosteroids for acute pancreatitis in dogs and investigate the therapeutic efficacy and prognosis.
Materials and Methods
Sixty‐five dogs were included in this non‐blinded, non‐randomised clinical study. Dogs with acute pancreatitis received treatment either with dose of 1 mg/kg/day prednisolone (n=45) or without prednisolone (n=20). Response to treatment was based on changes in the C‐reactive protein concentration, improvement in clinical signs, duration of hospitalisation, mortality and recurrence rate.
Results
From the third day of hospitalisation, C‐reactive protein concentration was significantly lower in the prednisolone group than that in the non‐prednisolone group. The number of days required to reach a C‐reactive protein concentration of <2 mg/dL and clinical score of ≤2 was significantly lower in the prednisolone group. The mortality rate 1 month after discharge was significantly lower in the prednisolone group (11.3% versus 46.1%).
Clinical Significance
In dogs with acute pancreatitis, initial treatment with prednisolone resulted in earlier reductions in C‐reactive protein concentration and earlier improvement of clinical signs.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>30868606</pmid><doi>10.1111/jsap.12994</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-7076-3682</orcidid></addata></record> |
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| ispartof | Journal of small animal practice, 2019-05, Vol.60 (5), p.298-304 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Acute Disease Adrenal Cortex Hormones Animals C-Reactive Protein - analysis Corticoids Corticosteroids Dog Diseases Dogs Mortality Pancreatitis Pancreatitis - veterinary Prednisolone Proteins |
| title | Comparison of initial treatment with and without corticosteroids for suspected acute pancreatitis in dogs |
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