Once-Daily Netarsudil Versus Twice-Daily Timolol in Patients With Elevated Intraocular Pressure: The Randomized Phase 3 ROCKET-4 Study

To compare the intraocular pressure (IOP)-lowering efficacy and safety of netarsudil once daily (QD) and timolol twice daily (BID). Double-masked, randomized, phase 3, noninferiority study. Patients with open-angle glaucoma or ocular hypertension (unmedicated baseline IOP >20 to

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Bibliographische Detailangaben
Veröffentlicht in:	American journal of ophthalmology 2019-08, Vol.204, p.97-104
Hauptverfasser:	Khouri, Albert S., Serle, Janet B., Bacharach, Jason, Usner, Dale W., Lewis, Richard A., Braswell, Puiwah, Kopczynski, Casey C., Heah, Theresa, Benza, Robert, Boyle, John W., Butler, Michelle, Cacioppo, Leonard Robert, Cardona, Jose F., Colborn, Valerie A., Day, Douglas G., Douglass, David T., El-Harazi, Sherif M., Ghate, Deepta, Hartman, Carl, Haverly, Robert F., Katzman, Barry, Kim, Max, Koo, Edward Y., Korenfeld, Michael S., Kwapiszeski, Bradley, Lane, Lydia, Lin, Christopher, Logan, Andrew Gardner, Lozier, Jeffrey Raymond, McQuirter, Henry, Mundorf, Thomas K., Olander, Kenneth, Ou, Richard J., Panzo, Gregory J., Peace, James H., Protzko, Eugene E., Ritch, Robert, Sall, Kenneth, Schechter, Barry A., Seltzer, Samuel Eric, Shah, Pankajkumar G., Sharpe, Elizabeth, Lee Shettle, Philip, Shulman, David G., Singh, Inder Paul, Smith, Stacy R., Smith, Stephen E., Smyth-Medina, Robert John, Sorenson, Robert C., Sturm, Richard, Sulkowski, Gregory M., Sutton, James D., Tepedino, Michael, Tsai, Julie, Tubbs, Carl B., Tukel, David B., Walters, Thomas Richard, Wirta, David L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antihypertensive Agents - administration & dosage Benzoates - administration & dosage beta-Alanine - administration & dosage beta-Alanine - analogs & derivatives Diabetic retinopathy Dose-Response Relationship, Drug Double-Blind Method Drug Administration Schedule Female Follow-Up Studies Glaucoma Glaucoma, Open-Angle - drug therapy Glaucoma, Open-Angle - physiopathology Humans Hypertension Intraocular Pressure - drug effects Intraocular Pressure - physiology Male Middle Aged Ocular Hypertension - drug therapy Ocular Hypertension - physiopathology Ophthalmic Solutions - administration & dosage Ophthalmology Retrospective Studies Timolol - administration & dosage Tonometry, Ocular Treatment Outcome
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Beschreibung
Zusammenfassung:	To compare the intraocular pressure (IOP)-lowering efficacy and safety of netarsudil once daily (QD) and timolol twice daily (BID). Double-masked, randomized, phase 3, noninferiority study. Patients with open-angle glaucoma or ocular hypertension (unmedicated baseline IOP >20 to
ISSN:	0002-9394 1879-1891
DOI:	10.1016/j.ajo.2019.03.002