Expression and functional relevance of long non-coding RNAs in acute myeloid leukemia stem cells

Expression and functional relevance of long non-coding RNAs in acute myeloid leukemia stem cells

In acute myeloid leukemia (AML), novel therapies are needed to target not only the rapidly dividing AML blasts but also the distinct population of leukemia stem cells (LSCs), which have abnormal self-renewal capacity and increased chemotherapy resistance. Elucidation of the expression and function o...

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Veröffentlicht in:Leukemia 2019-09, Vol.33 (9), p.2169-2182
Hauptverfasser: Bill, Marius, Papaioannou, Dimitrios, Karunasiri, Malith, Kohlschmidt, Jessica, Pepe, Felice, Walker, Christopher J., Walker, Allison E., Brannan, Zachary, Pathmanathan, Aparna, Zhang, Xiaoli, Mrózek, Krzysztof, LaRocco, Allison, Volinia, Stefano, Bloomfield, Clara D., Garzon, Ramiro, Dorrance, Adrienne M.
Format: Artikel
Sprache:eng
Schlagworte:
38/91
631/532/71
631/67/1990/283/1897
Acute Disease
Acute myeloid leukemia
Animal models
Animals
Cancer
Cancer Research
Cell Self Renewal - genetics
Cell self-renewal
Chemoresistance
Chemotherapy
Critical Care Medicine
Deregulation
Female
Gene expression
Hematology
Humans
Intensive
Internal Medicine
Leukemia
Leukemia, Myeloid, Acute - genetics
Leukemia, Myeloid, Acute - metabolism
Male
Medicine
Medicine & Public Health
Mice
Middle Aged
Myeloid leukemia
Neoplastic Stem Cells - metabolism
Non-coding RNA
Oncology
Reproduction (copying)
Ribonucleic acid
RNA
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
Stem cell transplantation
Stem cells
Transplantation
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Zusammenfassung:In acute myeloid leukemia (AML), novel therapies are needed to target not only the rapidly dividing AML blasts but also the distinct population of leukemia stem cells (LSCs), which have abnormal self-renewal capacity and increased chemotherapy resistance. Elucidation of the expression and function of deregulated genes in LSCs is critical to specifically target LSCs and may consequently lead to improving outcomes of AML patients. Here, we correlated long non-coding RNA (lncRNA) expression profiles obtained from two RNA-seq datasets of 375 younger (aged
ISSN:0887-6924
1476-5551
1476-5551
DOI:10.1038/s41375-019-0429-5