NAD-biosynthetic pathways regulate innate immunity

NAD-biosynthetic pathways regulate innate immunity

Recent studies indicate that macrophages utilize NAD + -biosynthetic pathways to control inflammation and cell survival during the immune response and aging.

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Bibliographische Detailangaben
Veröffentlicht in:Nature immunology 2019-04, Vol.20 (4), p.380-382
Hauptverfasser: Billingham, Leah K., Chandel, Navdeep S.
Format: Artikel
Sprache:eng
Schlagworte:
631/250/2504/342
631/80/642/333
Aging
Aging (Biology)
Biomedical and Life Sciences
Biomedicine
Biosynthetic Pathways
Cell survival
DNA Damage
Gene expression
Immune response
Immunity (Physiology)
Immunity, Innate
Immunology
Infectious Diseases
Inflammation
Innate immunity
Macrophages
Medical schools
NAD
News & Views
news-and-views
Niacinamide
Nicotinamide adenine dinucleotide
Purines
Reactive Oxygen Species
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Beschreibung
Zusammenfassung:Recent studies indicate that macrophages utilize NAD + -biosynthetic pathways to control inflammation and cell survival during the immune response and aging.
ISSN:1529-2908
1529-2916
DOI:10.1038/s41590-019-0353-x