Apolipoprotein E allelic variants and cerebral palsy
Gümüş E, Aras BD, Çilingir O, Yarar C, Çarman KB, Laçiner-Gürlevik S, Koçak O, Artan S. Apolipoprotein E allelic variants and cerebral palsy. Turk J Pediatr 2018; 60: 361-371. Cerebral palsy (CP) is the most frequent cause of mobility restriction and posture disturbance in childhood. Against the com...
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creator | Gümüş, Evren Aras, Beyhan Durak Çilingir, Oğuz Yarar, Coşkun Çarman, Kürşat Bora Laçiner-Gürlevik, Sibel Koçak, Ozan Artan, Sevilhan |
description | Gümüş E, Aras BD, Çilingir O, Yarar C, Çarman KB, Laçiner-Gürlevik S, Koçak O, Artan S. Apolipoprotein E allelic variants and cerebral palsy. Turk J Pediatr 2018; 60: 361-371. Cerebral palsy (CP) is the most frequent cause of mobility restriction and posture disturbance in childhood. Against the complexity in disease etiology, genetic factors, including Apolipoprotein E allelic distribution in this patient population, are worthy targets for investigation. ApoE is a lipoprotein of central nervous system encoded by ApoE gene with its 3 main co-dominant alleles, 2, 3 and 4. We aimed to evaluate the allelic frequencies of ApoE gene and its association with coexisting clinical entities such as vision and hearing impairment, cognitive problems, seizures and MRI findings in a pediatric patient population native to middle Anatolian region. Seventy-eight children with CP and 60 healthy controls were genotyped. Genotypic variations along with coexisting clinical conditions and CP-related medical findings were compared between the patient and control groups. The Denver Developmental Screening Test for all, the Wechsler Intelligence Scale for Children-IV (short form WISC-IV; Turkish version) for the patients > 6y and the Stanford-Binet Intelligence Scale (SB-5) for those who aged 2-6 years old were employed to evaluate cognitive and mental abilities of the patients. ApoE 2 and 4 alleles were more frequent in the patient group (p < 0.05), whereas ApoE 3 allele was more frequent in the healthy controls. ApoE 2/4 genotype has been determined 29% in the case group, but none in healthy control group. In the patient group with apolipoprotein 4 or 2 alleles, the rate of emergency cesarean section was found being significantly higher than the group with 3 allele. Brain MRI findings were not significantly different among ApoE allelic variants within the patient group. Our data show that the ApoE alleles may be effective in the development of cerebral palsy and may be associated with some clinical manifestations in those patients. |
doi_str_mv | 10.24953/turkjped.2018.04.002 |
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Apolipoprotein E allelic variants and cerebral palsy. Turk J Pediatr 2018; 60: 361-371. Cerebral palsy (CP) is the most frequent cause of mobility restriction and posture disturbance in childhood. Against the complexity in disease etiology, genetic factors, including Apolipoprotein E allelic distribution in this patient population, are worthy targets for investigation. ApoE is a lipoprotein of central nervous system encoded by ApoE gene with its 3 main co-dominant alleles, 2, 3 and 4. We aimed to evaluate the allelic frequencies of ApoE gene and its association with coexisting clinical entities such as vision and hearing impairment, cognitive problems, seizures and MRI findings in a pediatric patient population native to middle Anatolian region. Seventy-eight children with CP and 60 healthy controls were genotyped. Genotypic variations along with coexisting clinical conditions and CP-related medical findings were compared between the patient and control groups. The Denver Developmental Screening Test for all, the Wechsler Intelligence Scale for Children-IV (short form WISC-IV; Turkish version) for the patients > 6y and the Stanford-Binet Intelligence Scale (SB-5) for those who aged 2-6 years old were employed to evaluate cognitive and mental abilities of the patients. ApoE 2 and 4 alleles were more frequent in the patient group (p < 0.05), whereas ApoE 3 allele was more frequent in the healthy controls. ApoE 2/4 genotype has been determined 29% in the case group, but none in healthy control group. In the patient group with apolipoprotein 4 or 2 alleles, the rate of emergency cesarean section was found being significantly higher than the group with 3 allele. Brain MRI findings were not significantly different among ApoE allelic variants within the patient group. Our data show that the ApoE alleles may be effective in the development of cerebral palsy and may be associated with some clinical manifestations in those patients.</description><identifier>ISSN: 0041-4301</identifier><identifier>EISSN: 2791-6421</identifier><identifier>DOI: 10.24953/turkjped.2018.04.002</identifier><identifier>PMID: 30859759</identifier><language>eng</language><publisher>Turkey: Hacettepe University Faculty of Medicine</publisher><subject>Alzheimer's disease ; Apolipoproteins ; Brain research ; Cerebral palsy ; Children & youth ; Cognitive ability ; Convulsions & seizures ; Etiology ; Gene expression ; Genotype & phenotype ; Health risk assessment ; Medical imaging ; Nervous system ; Patients ; Studies</subject><ispartof>Turkish journal of pediatrics, 2018, Vol.60 (4), p.361-371</ispartof><rights>Copyright Hacettepe University Faculty of Medicine Jul/Aug 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-d1a6342ca0105157e62a333e73d5dc4696eb72c3dd473e92c9724399ae36a0d83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30859759$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gümüş, Evren</creatorcontrib><creatorcontrib>Aras, Beyhan Durak</creatorcontrib><creatorcontrib>Çilingir, Oğuz</creatorcontrib><creatorcontrib>Yarar, Coşkun</creatorcontrib><creatorcontrib>Çarman, Kürşat Bora</creatorcontrib><creatorcontrib>Laçiner-Gürlevik, Sibel</creatorcontrib><creatorcontrib>Koçak, Ozan</creatorcontrib><creatorcontrib>Artan, Sevilhan</creatorcontrib><title>Apolipoprotein E allelic variants and cerebral palsy</title><title>Turkish journal of pediatrics</title><addtitle>Turk J Pediatr</addtitle><description>Gümüş E, Aras BD, Çilingir O, Yarar C, Çarman KB, Laçiner-Gürlevik S, Koçak O, Artan S. Apolipoprotein E allelic variants and cerebral palsy. Turk J Pediatr 2018; 60: 361-371. Cerebral palsy (CP) is the most frequent cause of mobility restriction and posture disturbance in childhood. Against the complexity in disease etiology, genetic factors, including Apolipoprotein E allelic distribution in this patient population, are worthy targets for investigation. ApoE is a lipoprotein of central nervous system encoded by ApoE gene with its 3 main co-dominant alleles, 2, 3 and 4. We aimed to evaluate the allelic frequencies of ApoE gene and its association with coexisting clinical entities such as vision and hearing impairment, cognitive problems, seizures and MRI findings in a pediatric patient population native to middle Anatolian region. Seventy-eight children with CP and 60 healthy controls were genotyped. Genotypic variations along with coexisting clinical conditions and CP-related medical findings were compared between the patient and control groups. The Denver Developmental Screening Test for all, the Wechsler Intelligence Scale for Children-IV (short form WISC-IV; Turkish version) for the patients > 6y and the Stanford-Binet Intelligence Scale (SB-5) for those who aged 2-6 years old were employed to evaluate cognitive and mental abilities of the patients. ApoE 2 and 4 alleles were more frequent in the patient group (p < 0.05), whereas ApoE 3 allele was more frequent in the healthy controls. ApoE 2/4 genotype has been determined 29% in the case group, but none in healthy control group. In the patient group with apolipoprotein 4 or 2 alleles, the rate of emergency cesarean section was found being significantly higher than the group with 3 allele. Brain MRI findings were not significantly different among ApoE allelic variants within the patient group. Our data show that the ApoE alleles may be effective in the development of cerebral palsy and may be associated with some clinical manifestations in those patients.</description><subject>Alzheimer's disease</subject><subject>Apolipoproteins</subject><subject>Brain research</subject><subject>Cerebral palsy</subject><subject>Children & youth</subject><subject>Cognitive ability</subject><subject>Convulsions & seizures</subject><subject>Etiology</subject><subject>Gene expression</subject><subject>Genotype & phenotype</subject><subject>Health risk assessment</subject><subject>Medical imaging</subject><subject>Nervous system</subject><subject>Patients</subject><subject>Studies</subject><issn>0041-4301</issn><issn>2791-6421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkEtLAzEUhYMotlZ_gjLgxs2MN69JsiylPqDgRtchTVKYms6MyYzQf2-q7cbVWdzvHC4fQrcYKsIUp4_DGD-3vXcVASwrYBUAOUNTIhQua0bwOZoCMFwyCniCrlLaZkCAEpdoQkFyJbiaIjbvu9D0XR-7wTdtsSxMCD40tvg2sTHtkArTusL66NfRhKI3Ie2v0cUmp7855gx9PC3fFy_l6u35dTFflZZKNpQOm5oyYg1g4JgLXxNDKfWCOu4sq1Xt14JY6hwT1CtilSCMKmU8rQ04SWfo4W83f_c1-jToXZOsD8G0vhuTJlgBkxwwz-j9P3TbjbHN3x0oyTCT6jDI_ygbu5Si3-g-NjsT9xqD_tWqT1r1QasGprO13Ls7ro_rXb6dWieP9Aet93PA</recordid><startdate>2018</startdate><enddate>2018</enddate><creator>Gümüş, Evren</creator><creator>Aras, Beyhan Durak</creator><creator>Çilingir, Oğuz</creator><creator>Yarar, Coşkun</creator><creator>Çarman, Kürşat Bora</creator><creator>Laçiner-Gürlevik, Sibel</creator><creator>Koçak, Ozan</creator><creator>Artan, Sevilhan</creator><general>Hacettepe University Faculty of Medicine</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>EDSIH</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>2018</creationdate><title>Apolipoprotein E allelic variants and cerebral palsy</title><author>Gümüş, Evren ; 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Apolipoprotein E allelic variants and cerebral palsy. Turk J Pediatr 2018; 60: 361-371. Cerebral palsy (CP) is the most frequent cause of mobility restriction and posture disturbance in childhood. Against the complexity in disease etiology, genetic factors, including Apolipoprotein E allelic distribution in this patient population, are worthy targets for investigation. ApoE is a lipoprotein of central nervous system encoded by ApoE gene with its 3 main co-dominant alleles, 2, 3 and 4. We aimed to evaluate the allelic frequencies of ApoE gene and its association with coexisting clinical entities such as vision and hearing impairment, cognitive problems, seizures and MRI findings in a pediatric patient population native to middle Anatolian region. Seventy-eight children with CP and 60 healthy controls were genotyped. Genotypic variations along with coexisting clinical conditions and CP-related medical findings were compared between the patient and control groups. The Denver Developmental Screening Test for all, the Wechsler Intelligence Scale for Children-IV (short form WISC-IV; Turkish version) for the patients > 6y and the Stanford-Binet Intelligence Scale (SB-5) for those who aged 2-6 years old were employed to evaluate cognitive and mental abilities of the patients. ApoE 2 and 4 alleles were more frequent in the patient group (p < 0.05), whereas ApoE 3 allele was more frequent in the healthy controls. ApoE 2/4 genotype has been determined 29% in the case group, but none in healthy control group. In the patient group with apolipoprotein 4 or 2 alleles, the rate of emergency cesarean section was found being significantly higher than the group with 3 allele. Brain MRI findings were not significantly different among ApoE allelic variants within the patient group. Our data show that the ApoE alleles may be effective in the development of cerebral palsy and may be associated with some clinical manifestations in those patients.</abstract><cop>Turkey</cop><pub>Hacettepe University Faculty of Medicine</pub><pmid>30859759</pmid><doi>10.24953/turkjped.2018.04.002</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Alzheimer's disease Apolipoproteins Brain research Cerebral palsy Children & youth Cognitive ability Convulsions & seizures Etiology Gene expression Genotype & phenotype Health risk assessment Medical imaging Nervous system Patients Studies |
title | Apolipoprotein E allelic variants and cerebral palsy |
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