Association of Autoimmune Connective Tissue Disease and Outcomes in Patients Undergoing Transcatheter Aortic Valve Implantation

Patients with autoimmune connective tissue disease (CTD) are at higher risk for developing aortic valve pathology, but the safety and value of transcatheter aortic valve implantation (TAVI) in this population has not been investigated. This study evaluated mortality, complication, and readmission ra...

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Veröffentlicht in:	The American journal of cardiology 2019-05, Vol.123 (10), p.1675-1680
Hauptverfasser:	Rudasill, Sarah E., Sanaiha, Yas, Xing, Hanning, Mardock, Alexandra L., Khoury, Habib, Jaman, Rakin, Ebrahimi, Ramin, Benharash, Peyman
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aged, 80 and over Aortic valve Aortic Valve Stenosis - epidemiology Aortic Valve Stenosis - etiology Aortic Valve Stenosis - surgery Arthritis Autoimmune diseases Autoimmune Diseases - complications Autoimmune Diseases - mortality Chronic conditions Complications Connective tissue diseases Connective Tissue Diseases - complications Connective Tissue Diseases - mortality Connective tissues Costs Diabetes Diagnosis related groups DRGs Female Health risk assessment Health risks Heart failure Hospitalization Humans Hypertension Implantation Incidence Infections Insurance coverage Lung diseases Lupus Male Medicaid Medicare Morbidity Mortality Patients Postoperative Complications - epidemiology Postoperative infection Propensity Score Retrospective Studies Rheumatoid arthritis Risk analysis Risk Assessment - methods Risk factors Scleroderma Sepsis Septicemia Survival Rate - trends Systemic lupus erythematosus Tissues Transcatheter Aortic Valve Replacement - methods Transplants & implants United States - epidemiology
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Zusammenfassung:	Patients with autoimmune connective tissue disease (CTD) are at higher risk for developing aortic valve pathology, but the safety and value of transcatheter aortic valve implantation (TAVI) in this population has not been investigated. This study evaluated mortality, complication, and readmission rates along with length of stay and total costs after TAVI in patients with CTD. We retrospectively reviewed 47,216 patients who underwent TAVI from the National Readmissions Database between January 2011 and September 2015. Patients with systemic lupus erythematosus, scleroderma, rheumatoid arthritis, and other autoimmune CTD comprised the cohort. The primary outcome was mortality at index hospitalization. The 2,557 CTD patients (5.4%) had a higher Elixhauser co-morbidity index (7.1 vs 6.1, p
ISSN:	0002-9149 1879-1913
DOI:	10.1016/j.amjcard.2019.02.023