Effect of Continuous Positive Airway Pressure on Blood Pressure in Obstructive Sleep Apnea with Cardiovascular Disease

Cox regression models were also developed to explore whether BP change and BPV were independent predictors of the primary composite CV outcome (any one of CV death, myocardial infarction [MI], stroke, and hospitalization for heart failure, acute coronary syndrome, or transient ischemic attack), and separately for stroke and MI. Body mass index, apnea–hypopnea index, Epworth Sleepiness Scale score >10, country, smoking status, use of calcium channel blockers and/or beta blockers at baseline (because of their influence on BPV [9]), treatment group (CPAP or UC), and past medical histories of hypertension, MI, stroke, and diabetes mellitus were assessed and added if they resulted in significant improvement in −2 log likelihood and P