Qingyi Decoction amerliorates acute biliary pancreatitis by targeting Gpbar1/NF-kb pathway

Acute biliary pancreatitis (ABP) is a potentially life-threatening disease that is induced by the common bile duct (CBD) sludge or stones. This study aimed to investigate protective effects of Qingyi Decoction (QYT) on deoxycholic-acid-sodium salt (DCA) induced ABP in rats. Gpbar1 is a G-protein cou...

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Veröffentlicht in:	Frontiers in bioscience 2019-03, Vol.24 (5), p.833-848, Article 4754
Hauptverfasser:	Zhang, Gui-Xin, Zhan, Chen, Wang, Kai, Han, Jian, Shang, Dong, Chen, Hai-Iong
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Apoptosis Caspase 8 - metabolism Caspase 9 - metabolism Cell Line Drugs, Chinese Herbal - pharmacology Gene Expression Regulation, Enzymologic Inflammation NF-kappa B - metabolism Pancreatitis - drug therapy Pancreatitis - metabolism Rats Rats, Sprague-Dawley Receptors, G-Protein-Coupled - metabolism Signal Transduction
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Beschreibung
Zusammenfassung:	Acute biliary pancreatitis (ABP) is a potentially life-threatening disease that is induced by the common bile duct (CBD) sludge or stones. This study aimed to investigate protective effects of Qingyi Decoction (QYT) on deoxycholic-acid-sodium salt (DCA) induced ABP in rats. Gpbar1 is a G-protein coupled receptor that can be activated by DCA. Both Gpbar1 overexpression vector and Gpbar1 RNAi were constructed and transfected into ABP cell models. Functional assays reveal that DCA significantly induced AR42J apoptosis and triggered Gpbar1 expression. Gpbar1 significantly activated caspase 8 and caspase 9 as compared to LV5-NC and LV3-NC (p
ISSN:	1093-9946 2768-6698 1093-4715
DOI:	10.2741/4754