Sample matrix and high-sensitivity cardiac troponin I assays

Sample matrix and high-sensitivity cardiac troponin I assays

Background Manufacturers of high-sensitivity cardiac troponin (hs-cTn) assays have restricted use of what sample types or matrices are acceptable to use for measurement. Our goal was to evaluate the comparability of the Siemens ADVIA Centaur hs-cTnI assay across different matrices and under differen...

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Veröffentlicht in:Clinical chemistry and laboratory medicine 2019-04, Vol.57 (5), p.745-751
Hauptverfasser: Kavsak, Peter A., Roy, Chantele, Malinowski, Paul, Clark, Lorna, Lamers, Shana, Bamford, Karen, Hill, Stephen, Worster, Andrew, Jaffe, Allan S.
Format: Artikel
Sprache:eng
Schlagworte:
analytical variation
Anticoagulants
Assaying
Blood Chemical Analysis - standards
Blood Specimen Collection
Calcium-binding protein
Edetic acid
Edetic Acid - chemistry
EDTA plasma
Ethylenediaminetetraacetic acids
Heart
Heparin
Heparin - chemistry
high-sensitivity cardiac troponin
Humans
Immunoassay - standards
Lithium
lithium heparin plasma
matrix
Plasma
Quality Control
Reference Values
Sensitivity
serum
Slope stability
stability
Stability analysis
Storage
Storage conditions
Troponin
Troponin I
Troponin I - blood
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Zusammenfassung:Background Manufacturers of high-sensitivity cardiac troponin (hs-cTn) assays have restricted use of what sample types or matrices are acceptable to use for measurement. Our goal was to evaluate the comparability of the Siemens ADVIA Centaur hs-cTnI assay across different matrices and under different storage conditions. Methods Three different QC-plasma matrices were evaluated for imprecision
ISSN:1434-6621
1437-4331
DOI:10.1515/cclm-2018-1100