Miscibility studies of plastic-mimetic polypeptide with hydroxypropylmethylcellulose blends and generation of non-woven fabrics

•Synthesized the plastic-derived polypentapeptide by the solution phase method.•Investigated the miscibility characteristics of PLP/HPMC blends in both solution and solid phase.•DSC showed the single Tg up to 40% of the polypeptide in the mixture.•Miscible blends showed improved thermal stability.•Generated the non-woven fabrics with a fiber size of 80–100 nm at 22–24 kV by electrospinning technique. In the current investigation, the results of viscometric measurements, thermal property, SEM, XRD and FTIR of the polymer blends containing synthetic plastic-based polypeptide (PLP) with hydroxypropylmethylcellulose (HPMC) on miscibility is discussed. Various interaction parameters; KH, Δ[η]m, ΔB, μ, α, β and ΔK indicated the miscibility of polypeptide/HPMC up to 40% of the PLP in the blend at room temperature. The calorimetric results a single glass transition event for miscible systems. Further, the results were aligned with the scanning electron microscope and XRD analysis. Details concerning the nature of interactions in these systems and how they are influenced by the peptide proportion in the blends are discussed. The thermo gravimetric analysis manifested the improved thermal stability of the blends than their individual polymers. Additionally, the blend solutions were fabricated into non-woven fabrics with electrospinning technique, which may be a good candidate for pharmaceutical and biomedical applications.