Hematopoietic Stem Cell Transplantation Beyond Severe Combined Immunodeficiency: Seeking a Cure for Primary Immunodeficiency

Hematopoietic Stem Cell Transplantation Beyond Severe Combined Immunodeficiency: Seeking a Cure for Primary Immunodeficiency

Hematopoietic stem cell transplantation (HSCT) can provide definitive therapy for patients with primary immunodeficiency disease (PIDD). Modern HSCT techniques and supportive care have significantly improved outcomes for patients with PIDD. This review examines current HSCT practice for PIDD other t...

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Veröffentlicht in:The journal of allergy and clinical immunology in practice (Cambridge, MA) MA), 2019-03, Vol.7 (3), p.776-785
1. Verfasser: Mitchell, Richard
Format: Artikel
Sprache:eng
Schlagworte:
Accreditation
Copyright
Drug therapy
Health education
Hematopoietic stem cell transplantation
Hematopoietic stem cells
Infections
Kinases
Laboratories
Medical prognosis
Minority & ethnic groups
Mortality
Primary immunodeficiencies
Primary immunodeficiency
Reduced intensity conditioning
Severe combined immunodeficiency
Stem cell transplantation
Stem cells
Transplants & implants
Umbilical cord
Viral infections
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Beschreibung
Zusammenfassung:Hematopoietic stem cell transplantation (HSCT) can provide definitive therapy for patients with primary immunodeficiency disease (PIDD). Modern HSCT techniques and supportive care have significantly improved outcomes for patients with PIDD. This review examines current HSCT practice for PIDD other than severe combined immunodeficiency, and explores indications, risks, and long-term outcomes for this group of challenging diseases.
ISSN:2213-2198
2213-2201
DOI:10.1016/j.jaip.2018.12.011