Double‐lung versus heart‐lung transplantation for precapillary pulmonary arterial hypertension: a 24‐year single‐center retrospective study

Summary Transplant type for end‐stage pulmonary vascular disease remains debatable. We compared recipient outcome after heart‐lung (HLT) versus double‐lung (DLT) transplantation. Single‐center analysis (38 HLT–30 DLT; 1991–2014) for different causes of precapillary pulmonary hypertension (PH): idiop...

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Veröffentlicht in:	Transplant international 2019-07, Vol.32 (7), p.717-729
Hauptverfasser:	Brouckaert, Janne, Verleden, Stijn E., Verbelen, Tom, Coosemans, Willy, Decaluwé, Herbert, De Leyn, Paul, Depypere, Lieven, Nafteux, Philippe, Van Veer, Hans, Meyns, Bart, Rega, Filip, Van De Velde, Marc, Poortmans, Gert, Rex, Steffen, Neyrinck, Arne, Van den Berghe, Greet, Vlasselaers, Dirk, Van Cleemput, Johan, Budts, Werner, Vos, Robin, Quarck, Rozenn, Belge, Catharina, Delcroix, Marion, Verleden, Geert M., Van Raemdonck, Dirk
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Bleeding Cardiovascular diseases Child Child, Preschool chronic thromboembolic pulmonary hypertension congenital heart disease Connective tissue diseases Connective Tissue Diseases - surgery Connective tissues Coronary artery disease Disease-Free Survival Eisenmenger syndrome Female Graft Survival Grafting Health risk assessment Heart Defects, Congenital - surgery Heart diseases Heart transplantation Heart-Lung Transplantation - methods Hospital Mortality Humans Hypertension Lung diseases Lung transplantation Lung Transplantation - methods Male Middle Aged Postoperative Complications Preoperative Period Primary Graft Dysfunction pulmonary arterial hypertension Pulmonary Arterial Hypertension - surgery Pulmonary hypertension pulmonary vascular disease Retrospective Studies Survival Thromboembolism Thromboembolism - surgery Transplantation Transplants & implants Vascular diseases Xenografts Young Adult
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Zusammenfassung:	Summary Transplant type for end‐stage pulmonary vascular disease remains debatable. We compared recipient outcome after heart‐lung (HLT) versus double‐lung (DLT) transplantation. Single‐center analysis (38 HLT–30 DLT; 1991–2014) for different causes of precapillary pulmonary hypertension (PH): idiopathic (22); heritable (two); drug‐induced (nine); hepato‐portal (one); connective tissue disease (four); congenital heart disease (CHD) (24); chronic thromboembolic PH (six). HLT decreased from 91.7% [1991–1995] to 21.4% [2010–2014]. Re‐intervention for bleeding was higher after HLT; (P = 0.06) while primary graft dysfunction grades 2 and 3 occurred more after DLT; (P
ISSN:	0934-0874 1432-2277
DOI:	10.1111/tri.13409