Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids

Bacterial infections, caused predominately by Gram-positive and Gram-negative organisms, are proliferation of harmful strains of bacteria on or inside the body. Hospital-acquired and community-acquired bacterial infections have already put a heavy burden on the global health system. Antibiotics which can disrupt the processes necessary for bacterial cell growth and proliferation are effective weapons to fight against bacterial infections. However, the overuse and misuse of antibiotics have led to a rise in antibiotic resistance, creating an urgent need to develop novel antibiotics. 1,2,3-Triazole hybrids possess a broad spectrum of chemotherapeutic properties, also demonstrated promising in vitro and in vivo anti-bacterial activities. This review covers the recent (2000–2019) advances of 1,2,3-triazole hybrids as potential anti-bacterial agents. The structure-activity relationship (SAR) is also discussed for further rational development of 1,2,3-triazole hybrids with higher potency against both drug-sensitive and drug-resistant pathogens. This review covers the recent advances of 1,2,3-triazole hybrids as potential anti-bacterial agents. Some of them exhibited excellent activity against both drug-sensitive and drug-resistant pathogens, and the most emblematic example is hybrid 50o which was comparable to or better than the first-line anti-bacterial agents, demonstrating the potential of 1,2,3-triazole hybrids as anti-bacterial candidates. The structure-activity relationship is also discussed for further rational development of 1,2,3-triazole hybrids with higher potency against both drug-sensitive and drug-resistant pathogens. [Display omitted] •This review covers the recent advances of 1,2,3-triazole hybrids as potential anti-bacterial agents.•Some of them exhibited excellent activity against both drug-sensitive and drug-resistant pathogens.•The structure-activity relationship was enriched.