Effect of the kaurenoic acid on genotoxicity and cell cycle progression in cervical cancer cells lines

Effect of the kaurenoic acid on genotoxicity and cell cycle progression in cervical cancer cells lines

•Toxicity of kaurenoic acid (KA) was evaluated in three cervical cancer cell lines: HeLa, CaSki and C33A.•KA showed a strong positive correlation with DNA damage and micronuclei frequency.•At high concentrations, the KA inhibited the expression of E6 and E7 HPV genes.•The assays pointed to the possi...

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Veröffentlicht in:Toxicology in vitro 2019-06, Vol.57, p.126-131
Hauptverfasser: Rocha, Silvia Maria Machado da, Cardoso, Plínio Cerqueira dos Santos, Bahia, Marcelo de Oliveira, Pessoa, Claudia do Ó, Soares, Paulo Cardoso, Rocha, Simone Machado da, Burbano, Rommel Mário Rodríguez, Rocha, Carlos Alberto Machado da
Format: Artikel
Sprache:eng
Schlagworte:
Cell cycle
Cervical cancer
Cervix
Genotoxicity
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Zusammenfassung:•Toxicity of kaurenoic acid (KA) was evaluated in three cervical cancer cell lines: HeLa, CaSki and C33A.•KA showed a strong positive correlation with DNA damage and micronuclei frequency.•At high concentrations, the KA inhibited the expression of E6 and E7 HPV genes.•The assays pointed to the possibility of using KA as feedstock for therapeutic agents against cervical cancer with HPV.
ISSN:0887-2333
1879-3177
DOI:10.1016/j.tiv.2019.02.022