Target-assisted self-cleavage DNAzyme probes for multicolor simultaneous imaging of tumor-related microRNAs with signal amplification

Target-assisted self-cleavage DNAzyme probes for multicolor simultaneous imaging of tumor-related microRNAs with signal amplification

In this work, we have developed a novel and highly selective signal amplification strategy based on target-assisted self-cleavage DNAzyme probes for multicolor and simultaneous imaging of miRNA-222 and miRNA-223 in living cells. The fluctuation of miRNA-222 and miRNA-223 expression levels could also...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2019-03, Vol.55 (22), p.3278-3281
Hauptverfasser: Wan, Yuan-Hui, Zhou, Yu-Jie, Xiao, Ke-Jing, Nie, Cun-Peng, Zhang, Juan, Liu, Chang, Chen, Ting-Ting, Chu, Xia
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Sprache:eng
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Amplification
Cleavage
Variations
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container_end_page 3281
container_issue 22
container_start_page 3278
container_title Chemical communications (Cambridge, England)
container_volume 55
creator Wan, Yuan-Hui
Zhou, Yu-Jie
Xiao, Ke-Jing
Nie, Cun-Peng
Zhang, Juan
Liu, Chang
Chen, Ting-Ting
Chu, Xia
description In this work, we have developed a novel and highly selective signal amplification strategy based on target-assisted self-cleavage DNAzyme probes for multicolor and simultaneous imaging of miRNA-222 and miRNA-223 in living cells. The fluctuation of miRNA-222 and miRNA-223 expression levels could also be monitored.
doi_str_mv 10.1039/c9cc00451c
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source Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
subjects Amplification
Cleavage
Variations
title Target-assisted self-cleavage DNAzyme probes for multicolor simultaneous imaging of tumor-related microRNAs with signal amplification
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