Target-assisted self-cleavage DNAzyme probes for multicolor simultaneous imaging of tumor-related microRNAs with signal amplification

Target-assisted self-cleavage DNAzyme probes for multicolor simultaneous imaging of tumor-related microRNAs with signal amplification

In this work, we have developed a novel and highly selective signal amplification strategy based on target-assisted self-cleavage DNAzyme probes for multicolor and simultaneous imaging of miRNA-222 and miRNA-223 in living cells. The fluctuation of miRNA-222 and miRNA-223 expression levels could also...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2019-03, Vol.55 (22), p.3278-3281
Hauptverfasser: Wan, Yuan-Hui, Zhou, Yu-Jie, Xiao, Ke-Jing, Nie, Cun-Peng, Zhang, Juan, Liu, Chang, Chen, Ting-Ting, Chu, Xia
Format: Artikel
Sprache:eng
Schlagworte:
Amplification
Cleavage
Variations
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Zusammenfassung:In this work, we have developed a novel and highly selective signal amplification strategy based on target-assisted self-cleavage DNAzyme probes for multicolor and simultaneous imaging of miRNA-222 and miRNA-223 in living cells. The fluctuation of miRNA-222 and miRNA-223 expression levels could also be monitored.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc00451c