Irisin and BDNF serum levels and behavioral disturbances in Alzheimer’s disease

Behavioral dysfunctions (BPSD) represent the most important problem in Alzheimer’s dementia (AD) management. We assessed the serum levels of two myokines in AD patients, preliminary investigating, as secondary aim, their role as potential biomarkers for agitation/aggression (AA) and aberrant motor b...

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Veröffentlicht in:	Neurological sciences 2019-06, Vol.40 (6), p.1145-1150
Hauptverfasser:	Conti, Elisa, Grana, Denise, Stefanoni, Giovanni, Corsini, Alberto, Botta, Margherita, Magni, Paolo, Aliprandi, Angelo, Lunetta, Christian, Appollonio, Ildebrando, Ferrarese, Carlo, Tremolizzo, Lucio
Format:	Artikel
Sprache:	eng
Schlagworte:	Agitation Alzheimer's disease Behavior Biomarkers Brain-derived neurotrophic factor Caregivers Cognitive ability Dementia Dementia disorders Enzyme-linked immunosorbent assay Exercise Hallucinations Hospitals Medicine Medicine & Public Health Motor activity Neurology Neuroradiology Neurosciences Neurosurgery Original Article Patients Physical fitness Psychiatry Psychosis Serum levels
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Zusammenfassung:	Behavioral dysfunctions (BPSD) represent the most important problem in Alzheimer’s dementia (AD) management. We assessed the serum levels of two myokines in AD patients, preliminary investigating, as secondary aim, their role as potential biomarkers for agitation/aggression (AA) and aberrant motor behavior (AMB): irisin, since it is able to modify the motor pattern, and BDNF, since it was transcribed following irisin stimulation. Forty AD patients were recruited and characterized according to the expressed neuropsychiatric syndrome. Myokines were measured by ELISA. Irisin serum levels were slightly elevated in AA+ patients (+ 10.0%; p
ISSN:	1590-1874 1590-3478
DOI:	10.1007/s10072-019-03781-y