Autologous nanofat transplantation accelerates foot wound healing in diabetic rats

This study explored the effects of local transplantation of autologous nanofat in the treatment of rats with diabetic foot wounds. Nanofat was transplanted into the left foot wound of diabetic rats. Phosphate-buffered saline injection in the right served as control. We measured wound size, the extent of epithelization, microvessel density and the expression levels of cytokines at six different time-points postoperation. Compared with the control feet, nanofat-treated feet had significantly smaller wound areas at 7 and 9 days after grafting and showed better re-epithelialization, a greater number of microvessels and higher levels of angiogenic factor expression. This research shows that autologous nanofat transplantation can promote diabetic foot wound healing in rats.