Effects of medication intake in early pregnancy on the fetal fraction of cell‐free DNA testing

Effects of medication intake in early pregnancy on the fetal fraction of cell‐free DNA testing

Objectives To determine the association between medications intake in early pregnancy and variation in the fetal fraction (FF) in pregnant women undergoing cell‐free DNA (cfDNA) testing. Methods We performed a retrospective cohort study of women (n = 1051) undergoing cfDNA testing at an academic cen...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Prenatal diagnosis 2019-04, Vol.39 (5), p.361-368
Hauptverfasser: Kuhlmann‐Capek, Maggie, Chiossi, Giuseppe, Singh, Prapti, Monsivais, Luis, Lozovyy, Violetta, Gallagher, Lauren, Kirsch, Nathan, Florence, Elizabeth, Petruzzi, Victoria, Chang, Jeffrey, Buenaventura, Sofia, Walden, Paul, Gardner, Benjamin, Munn, Mary, Costantine, Maged
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Cell-Free Nucleic Acids - drug effects
Deoxyribonucleic acid
DNA
DNA testing
Exposure
Female
Fetuses
Gestational age
Humans
Hypoglycemic Agents - adverse effects
Metformin
Metformin - adverse effects
Noninvasive Prenatal Testing
Obesity
Pregnancy
Retrospective Studies
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Objectives To determine the association between medications intake in early pregnancy and variation in the fetal fraction (FF) in pregnant women undergoing cell‐free DNA (cfDNA) testing. Methods We performed a retrospective cohort study of women (n = 1051) undergoing cfDNA testing at an academic center. The exposed group included women taking medications (n = 400; 38.1%), while the nonexposed group consisted of women taking no medications (n = 651; 61.9%). Our primary outcome was FF. We performed univariate and multivariate analyses as appropriate. Results The FFs were 8.8% (6.6‐12.1), 8.7% (6.3‐11.6), and 7.7% (5.1‐9.3) among women taking 0, 1, and two or more medications, respectively (P 
ISSN:0197-3851
1097-0223
DOI:10.1002/pd.5436