Moringa concanensis Nimmo extracts ameliorates hyperglycemia-mediated oxidative stress and upregulates PPARγ and GLUT4 gene expression in liver and pancreas of streptozotocin-nicotinamide induced diabetic rats

Moringa concanensis Nimmo extracts ameliorates hyperglycemia-mediated oxidative stress and upregulates PPARγ and GLUT4 gene expression in liver and pancreas of streptozotocin-nicotinamide induced diabetic rats

The current study investigates the effects of ethanolic extract of M. concanensis Nimmo leaves (EEMCNL) with respect to its potent protective tissue damage, antioxidant properties in serum, liver and kidney, histopathological evaluation, and PPARγ and GLUT4 gene expression in liver and pancreatic ti...

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Veröffentlicht in:Biomedicine & pharmacotherapy 2019-04, Vol.112, p.108688-108688, Article 108688
Hauptverfasser: Balakrishnan, Brindha Banu, Krishnasamy, Kalaivani, Mayakrishnan, Vijayakumar, Selvaraj, Arokiyaraj
Format: Artikel
Sprache:eng
Schlagworte:
Diabetes
GLUT4
Hepatic cells
Hyperglycemia
M. concanensis Nimmo
PPARγ
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Zusammenfassung:The current study investigates the effects of ethanolic extract of M. concanensis Nimmo leaves (EEMCNL) with respect to its potent protective tissue damage, antioxidant properties in serum, liver and kidney, histopathological evaluation, and PPARγ and GLUT4 gene expression in liver and pancreatic tissue of Streptozotocin-Nicotinamide (STZ-NA) induced diabetic rats. Animals were divided into five groups (n = 5): control; diabetic; diabetic + EEMCNL; control + EEMCNL; and diabetic + glibenclamide. After 45 days of treatment with EEMCNL, MDA levels were significantly decreased in the diabetic-induced group when compared with the STZ-induced diabetic group (P 
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2019.108688