Short-term effects of intravitreal bevacizumab in contrast sensitivity of patients with diabetic macular edema and optimizing glycemic control

•Anti-VEGF therapy associated with optimizing glicemic control leads to superior approach to the treatment of diabetic macular edema.•The contrast sensitivity could play an important role in the visual evaluation of diabetic macular edema.•Glycemic control with hemoglobin A1c levels shown to be effective in the follow-up of diabetic retinopathy. To analyze contrast sensitivity of intravitreal bevacizumab injections with optimizing glycemic control versus optimizing glycemic control (in combination with sham injections) in eyes with Diabetic Macular Edema (DME). Prospective, interventional, masked, randomized controlled trial. Forty-one eyes of 34 patients with type 2 diabetes mellitus and DME with glycated hemoglobin (HbA1c)