Choosing a Mouse Model of Venous Thrombosis

Murine models are widely used valuable tools to study deep vein thrombosis. Leading experts in venous thrombosis research came together through the American Venous Forum to develop a consensus on maximizing the utility and application of available mouse models of venous thrombosis. In this work, we...

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Hauptverfasser:	Diaz, Jose A, Saha, Prakash, Cooley, Brian, Palmer, Olivia R, Grover, Steven P, Mackman, Nigel, Wakefield, Thomas W, Henke, Peter K, Smith, Alberto, Lal, Brajesh K
Format:	Tagungsbericht
Sprache:	eng
Schlagworte:	Algorithms Animals Chlorides - toxicity Disease Models, Animal Electrolysis Endothelial Cells - drug effects Endothelium, Vascular - pathology Ferric Compounds - toxicity Free Radicals Hemorheology Ligation Mice Recurrence Research Design Veins - surgery Venous Thrombosis - chemically induced Venous Thrombosis - etiology Venous Thrombosis - physiopathology Venules
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Beschreibung
Zusammenfassung:	Murine models are widely used valuable tools to study deep vein thrombosis. Leading experts in venous thrombosis research came together through the American Venous Forum to develop a consensus on maximizing the utility and application of available mouse models of venous thrombosis. In this work, we provide an algorithm for model selection, with discussion of the advantages, disadvantages, and applications of the main mouse models of venous thrombosis. Additionally, we provide a detailed surgical description of the models with guidelines to validate surgical technique.
ISSN:	1524-4636
DOI:	10.1161/ATVBAHA.118.311818