Another look at phenolic compounds in cancer therapy the effect of polyphenols on ubiquitin-proteasome system

Inhibitors of the ubiquitin-proteasome system (UPS) have been the object of research interests for many years because of their potential as anti-cancer agents. Research in this field is aimed at improving the specificity and safety of known proteasome inhibitors. Unfortunately, in vitro conditions do not reflect the processes taking place in the human body. Recent reports indicate that the components of human plasma affect the course of many signaling pathways, proteasome activity and the effectiveness of synthetic cytostatic drugs. Therefore, it is believed that the key issue is to determine the effects of components of the human diet, including effects of chemically active polyphenols on the ubiquitin-proteasome system activity in both physiological and pathological (cancerous) states. The following article summarizes the current knowledge on the direct and indirect synergistic and antagonistic effects between polyphenolic compounds present in the human diet and the efficiency of protein degradation via the UPS. [Display omitted] •We have summarized the knowledge about the effect of polyphenols on the efficiency of protein degradation by UPS.•We described the synergistic and antagonistic effects between conventional UPS inhibitors and polyphenols.•We depicted the influence of the chemical structure of phenolic compounds on their activity in signaling pathways.•We underlined the importance of compounds in the diet for the effectiveness of cancer therapy.