Benzoxazine monomer derived carbon dots as a broad-spectrum agent to block viral infectivity
[Display omitted] Multiple viruses can cause infection and death of millions annually. Of these, flaviviruses are found to be highly prevalent in recent years with no distinctive antiviral therapies. Therefore, there is a desperate need for broad-spectrum antiviral drugs that can be active against a...
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| Veröffentlicht in: | Journal of colloid and interface science 2019-04, Vol.542, p.198-206 |
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| container_title | Journal of colloid and interface science |
| container_volume | 542 |
| creator | Huang, Shaomei Gu, Jiangjiang Ye, Jing Fang, Bin Wan, Shengfeng Wang, Caoyu Ashraf, Usama Li, Qi Wang, Xugang Shao, Lin Song, Yunfeng Zheng, Xinsheng Cao, Feifei Cao, Shengbo |
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Multiple viruses can cause infection and death of millions annually. Of these, flaviviruses are found to be highly prevalent in recent years with no distinctive antiviral therapies. Therefore, there is a desperate need for broad-spectrum antiviral drugs that can be active against a large number of existing and emerging viruses. Herein, we prepared a kind of benzoxazine monomer derived carbon dots (BZM-CDs) and demonstrated their infection-blocking ability against life-threatening flaviviruses (Japanese encephalitis, Zika, and dengue viruses) and non-enveloped viruses (porcine parvovirus and adenovirus-associated virus). It was found that BZM-CDs could directly bind to the surface of the virion, and eventually the first step of virus-cell interaction was impeded. The developed nanoparticles are active against both flaviviruses and non-enveloped viruses in vitro. Thus, the application of BZM-CDs may constitute an intriguing broad-spectrum approach to rein in viral infections. |
| doi_str_mv | 10.1016/j.jcis.2019.02.010 |
| format | Article |
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Multiple viruses can cause infection and death of millions annually. Of these, flaviviruses are found to be highly prevalent in recent years with no distinctive antiviral therapies. Therefore, there is a desperate need for broad-spectrum antiviral drugs that can be active against a large number of existing and emerging viruses. Herein, we prepared a kind of benzoxazine monomer derived carbon dots (BZM-CDs) and demonstrated their infection-blocking ability against life-threatening flaviviruses (Japanese encephalitis, Zika, and dengue viruses) and non-enveloped viruses (porcine parvovirus and adenovirus-associated virus). It was found that BZM-CDs could directly bind to the surface of the virion, and eventually the first step of virus-cell interaction was impeded. The developed nanoparticles are active against both flaviviruses and non-enveloped viruses in vitro. Thus, the application of BZM-CDs may constitute an intriguing broad-spectrum approach to rein in viral infections.</description><identifier>ISSN: 0021-9797</identifier><identifier>EISSN: 1095-7103</identifier><identifier>DOI: 10.1016/j.jcis.2019.02.010</identifier><identifier>PMID: 30739009</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Antivirus ; Benzoxazine monomers ; Broad-spectrum agents ; Carbon dots ; Flaviviruses</subject><ispartof>Journal of colloid and interface science, 2019-04, Vol.542, p.198-206</ispartof><rights>2019 Elsevier Inc.</rights><rights>Copyright © 2019 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-398d08571368f76cb2541066a01796d8756a3679869fca617627c04b979bcd893</citedby><cites>FETCH-LOGICAL-c356t-398d08571368f76cb2541066a01796d8756a3679869fca617627c04b979bcd893</cites><orcidid>0000-0002-5161-2571</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0021979719301742$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30739009$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Shaomei</creatorcontrib><creatorcontrib>Gu, Jiangjiang</creatorcontrib><creatorcontrib>Ye, Jing</creatorcontrib><creatorcontrib>Fang, Bin</creatorcontrib><creatorcontrib>Wan, Shengfeng</creatorcontrib><creatorcontrib>Wang, Caoyu</creatorcontrib><creatorcontrib>Ashraf, Usama</creatorcontrib><creatorcontrib>Li, Qi</creatorcontrib><creatorcontrib>Wang, Xugang</creatorcontrib><creatorcontrib>Shao, Lin</creatorcontrib><creatorcontrib>Song, Yunfeng</creatorcontrib><creatorcontrib>Zheng, Xinsheng</creatorcontrib><creatorcontrib>Cao, Feifei</creatorcontrib><creatorcontrib>Cao, Shengbo</creatorcontrib><title>Benzoxazine monomer derived carbon dots as a broad-spectrum agent to block viral infectivity</title><title>Journal of colloid and interface science</title><addtitle>J Colloid Interface Sci</addtitle><description>[Display omitted]
Multiple viruses can cause infection and death of millions annually. Of these, flaviviruses are found to be highly prevalent in recent years with no distinctive antiviral therapies. Therefore, there is a desperate need for broad-spectrum antiviral drugs that can be active against a large number of existing and emerging viruses. Herein, we prepared a kind of benzoxazine monomer derived carbon dots (BZM-CDs) and demonstrated their infection-blocking ability against life-threatening flaviviruses (Japanese encephalitis, Zika, and dengue viruses) and non-enveloped viruses (porcine parvovirus and adenovirus-associated virus). It was found that BZM-CDs could directly bind to the surface of the virion, and eventually the first step of virus-cell interaction was impeded. The developed nanoparticles are active against both flaviviruses and non-enveloped viruses in vitro. Thus, the application of BZM-CDs may constitute an intriguing broad-spectrum approach to rein in viral infections.</description><subject>Antivirus</subject><subject>Benzoxazine monomers</subject><subject>Broad-spectrum agents</subject><subject>Carbon dots</subject><subject>Flaviviruses</subject><issn>0021-9797</issn><issn>1095-7103</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kE1r3DAQhkVpSbZp_0APRcde7M5YsT6glzb0CwK9NLeAkKVx0da2tpJ3SfLro2XTHgsDc5jnfWEext4gtAgo32_brY-l7QBNC10LCM_YBsH0jUIQz9kGoMPGKKPO2ctStgCIfW_O2LkAJQyA2bDbT7Q8pDv3EBfic1rSTJkHyvFAgXuXh7TwkNbCXR0-5ORCU3bk17yfuftFy8rXxIcp-d_8ELObeFzGeo6HuN6_Yi9GNxV6_bQv2M2Xzz-vvjXXP75-v_p43XjRy7URRgfQvUIh9aikH7r-EkFKB6iMDFr10gmpjJZm9E6ikp3ycDnUzwYftBEX7N2pd5fTnz2V1c6xeJomt1DaF9uhFqhRaahod0J9TqVkGu0ux9nle4tgj1bt1h6t2qNVC52tVmvo7VP_fpgp_Iv81ViBDyeA6peHSNkWH2nxFGKuMmxI8X_9j_GCh-0</recordid><startdate>20190415</startdate><enddate>20190415</enddate><creator>Huang, Shaomei</creator><creator>Gu, Jiangjiang</creator><creator>Ye, Jing</creator><creator>Fang, Bin</creator><creator>Wan, Shengfeng</creator><creator>Wang, Caoyu</creator><creator>Ashraf, Usama</creator><creator>Li, Qi</creator><creator>Wang, Xugang</creator><creator>Shao, Lin</creator><creator>Song, Yunfeng</creator><creator>Zheng, Xinsheng</creator><creator>Cao, Feifei</creator><creator>Cao, Shengbo</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5161-2571</orcidid></search><sort><creationdate>20190415</creationdate><title>Benzoxazine monomer derived carbon dots as a broad-spectrum agent to block viral infectivity</title><author>Huang, Shaomei ; Gu, Jiangjiang ; Ye, Jing ; Fang, Bin ; Wan, Shengfeng ; Wang, Caoyu ; Ashraf, Usama ; Li, Qi ; Wang, Xugang ; Shao, Lin ; Song, Yunfeng ; Zheng, Xinsheng ; Cao, Feifei ; Cao, Shengbo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-398d08571368f76cb2541066a01796d8756a3679869fca617627c04b979bcd893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Antivirus</topic><topic>Benzoxazine monomers</topic><topic>Broad-spectrum agents</topic><topic>Carbon dots</topic><topic>Flaviviruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Shaomei</creatorcontrib><creatorcontrib>Gu, Jiangjiang</creatorcontrib><creatorcontrib>Ye, Jing</creatorcontrib><creatorcontrib>Fang, Bin</creatorcontrib><creatorcontrib>Wan, Shengfeng</creatorcontrib><creatorcontrib>Wang, Caoyu</creatorcontrib><creatorcontrib>Ashraf, Usama</creatorcontrib><creatorcontrib>Li, Qi</creatorcontrib><creatorcontrib>Wang, Xugang</creatorcontrib><creatorcontrib>Shao, Lin</creatorcontrib><creatorcontrib>Song, Yunfeng</creatorcontrib><creatorcontrib>Zheng, Xinsheng</creatorcontrib><creatorcontrib>Cao, Feifei</creatorcontrib><creatorcontrib>Cao, Shengbo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of colloid and interface science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Shaomei</au><au>Gu, Jiangjiang</au><au>Ye, Jing</au><au>Fang, Bin</au><au>Wan, Shengfeng</au><au>Wang, Caoyu</au><au>Ashraf, Usama</au><au>Li, Qi</au><au>Wang, Xugang</au><au>Shao, Lin</au><au>Song, Yunfeng</au><au>Zheng, Xinsheng</au><au>Cao, Feifei</au><au>Cao, Shengbo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Benzoxazine monomer derived carbon dots as a broad-spectrum agent to block viral infectivity</atitle><jtitle>Journal of colloid and interface science</jtitle><addtitle>J Colloid Interface Sci</addtitle><date>2019-04-15</date><risdate>2019</risdate><volume>542</volume><spage>198</spage><epage>206</epage><pages>198-206</pages><issn>0021-9797</issn><eissn>1095-7103</eissn><abstract>[Display omitted]
Multiple viruses can cause infection and death of millions annually. Of these, flaviviruses are found to be highly prevalent in recent years with no distinctive antiviral therapies. Therefore, there is a desperate need for broad-spectrum antiviral drugs that can be active against a large number of existing and emerging viruses. Herein, we prepared a kind of benzoxazine monomer derived carbon dots (BZM-CDs) and demonstrated their infection-blocking ability against life-threatening flaviviruses (Japanese encephalitis, Zika, and dengue viruses) and non-enveloped viruses (porcine parvovirus and adenovirus-associated virus). It was found that BZM-CDs could directly bind to the surface of the virion, and eventually the first step of virus-cell interaction was impeded. The developed nanoparticles are active against both flaviviruses and non-enveloped viruses in vitro. Thus, the application of BZM-CDs may constitute an intriguing broad-spectrum approach to rein in viral infections.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30739009</pmid><doi>10.1016/j.jcis.2019.02.010</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-5161-2571</orcidid></addata></record> |
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| subjects | Antivirus Benzoxazine monomers Broad-spectrum agents Carbon dots Flaviviruses |
| title | Benzoxazine monomer derived carbon dots as a broad-spectrum agent to block viral infectivity |
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