Bone Health in Patients with Type 2 Diabetes Treated by Roux-En-Y Gastric Bypass and the Role of Diabetes Remission

Background Roux-en-Y gastric bypass (RYGB) has been associated with negative effects on bone. Whether this association is affected by pre-surgical type 2 diabetes (T2D) and surgically induced diabetes remission is unknown. Methods In this cross-sectional, matched cohort study 6 years after RYGB, we...

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Veröffentlicht in:	Obesity surgery 2019-06, Vol.29 (6), p.1823-1831
Hauptverfasser:	Madsen, Lene Ring, Espersen, Rasmus, Ornstrup, Marie Juul, Jørgensen, Niklas Rye, Langdahl, Bente Lomholt, Richelsen, Bjørn
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorptiometry, Photon Body Mass Index Bone Density Bone Diseases, Metabolic - etiology Cohort Studies Cross-Sectional Studies Diabetes Diabetes Mellitus, Type 2 Female Gastric Bypass Humans Male Medicine Medicine & Public Health Middle Aged Obesity, Morbid - surgery Original Contributions Osteoporosis Postoperative Period Remission Induction Surgery
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Zusammenfassung:	Background Roux-en-Y gastric bypass (RYGB) has been associated with negative effects on bone. Whether this association is affected by pre-surgical type 2 diabetes (T2D) and surgically induced diabetes remission is unknown. Methods In this cross-sectional, matched cohort study 6 years after RYGB, we investigated bone health in 96 individuals with body mass index (BMI) > 35 kg/m 2 and T2D (stratified on current diabetes status) treated by RYGB 6 years earlier compared with 49 non-operated individuals with T2D matched with respect to sex, age, and current BMI. Main outcome measures were areal and volumetric bone mineral density (aBMD and vBMD), bone turnover, and odds ratio of osteoporosis/osteopenia. Results The RYGB group had lower hip (0.916 vs 1.010 g/cm 2 , p
ISSN:	0960-8923 1708-0428
DOI:	10.1007/s11695-019-03753-3