Role of adipocytokines in the integrated assessment of nutritional status of patients with a combination of hypertension and chronic obstructive pulmonary disease

The aim of the study was to identify early markers of diagnosis and efficacy of treatment of patients with arterial hypertension (AH) in combination with chronic obstructive pulmonary disease (COPD) basing on the study of adipocytokine and nutritional status. A comprehensive clinical and functional examination of 187 patients has been carried out, including 27 patients without AH and COPD that formed the control group, 53 patients with hypertension, 51 patients with COPD and 56 patients with hypertension combined with COPD. Examination of all patients included general clinical methods, evaluation of the indicators of respiratory function, daily monitoring of blood pressure. The level of adipokines in the blood was determined by ELISA; cytokine status indicators in blood serum - by electrochemiluminescent method; indicators of lipid, carbohydrate and protein metabolism - on the analyzer; evaluation of body composition by bioimpedance method. In the group of persons suffering from AH in combination with COPD, a significant prevalence of patients with a hemodynamic variant of non-dippers (48.2%) was found, a decrease in the indicators of external respiration function was revealed (the volume of forced expiration in the first second was statistically significantly 1.5 fold lower than the index of patients from the control group, the Tiffno index was 1.3 fold lower, p