Thin Skinned: Aged Adipocyte Atrophy Impacts Innate Immunity

In a recent study, Zhang et al. (Immunity 2019;50:121–136) report that adipocyte atrophy in aged skin increases susceptibility to bacterial infection. Enhanced TGF-β signaling in aged adipocyte progenitor cells induces a fibrotic cell fate that lacks antimicrobial peptides produced by mature adipocy...

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Veröffentlicht in:	Trends in immunology 2019-03, Vol.40 (3), p.175-177
Hauptverfasser:	Wasko, Renee R., Horsley, Valerie
Format:	Artikel
Sprache:	eng
Schlagworte:	adipocyte Adipocytes Adipocytes - metabolism Adipocytes - pathology Adipogenesis Adipose Tissue, White - pathology Age Aging Aging - physiology Animals Antimicrobial agents Antimicrobial Cationic Peptides - metabolism Antimicrobial peptides Atrophy bacterial infection Bacterial infections Cell fate Cells (biology) Disease Resistance Extracellular matrix fibroblast Fibrosis Growth factors Humans Immunity, Innate Immunology Innate immunity Investigations Mammals Mice Peptides Progenitor cells Skin Skin Physiological Phenomena Staphylococcal Infections - immunology Staphylococcus aureus - physiology Staphylococcus infections Stem cells Stromal cells TGF-β
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Beschreibung
Zusammenfassung:	In a recent study, Zhang et al. (Immunity 2019;50:121–136) report that adipocyte atrophy in aged skin increases susceptibility to bacterial infection. Enhanced TGF-β signaling in aged adipocyte progenitor cells induces a fibrotic cell fate that lacks antimicrobial peptides produced by mature adipocytes, highlighting the importance of stromal cells as innate immune effectors.
ISSN:	1471-4906 1471-4981
DOI:	10.1016/j.it.2019.01.009