Divergent expression of liver transforming growth factor superfamily cytokines after successful portoenterostomy in biliary atresia

Divergent expression of liver transforming growth factor superfamily cytokines after successful portoenterostomy in biliary atresia

Pathogenesis of progressive liver fibrosis in biliary atresia after successful portoenterostomy remains unclear. We related hepatic expression of transforming growth factor beta (TGF-β) superfamily cytokines to histologic liver injury after successful portoenterostomy. Enrolled in our study were 28...

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Veröffentlicht in:Surgery 2019-05, Vol.165 (5), p.905-911
Hauptverfasser: Kerola, Anna, Lohi, Jouko, Heikkilä, Päivi, Mutanen, Annika, Jalanko, Hannu, Pakarinen, Mikko P.
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Biliary Atresia - complications
Biliary Atresia - pathology
Biliary Atresia - surgery
Biopsy
Child
Child, Preschool
Cytokines - metabolism
Disease Progression
Female
Follow-Up Studies
Gene Expression Profiling
Humans
Liver - pathology
Liver - surgery
Liver Cirrhosis - etiology
Liver Cirrhosis - pathology
Liver Cirrhosis - prevention & control
Male
Portoenterostomy, Hepatic
Transforming Growth Factors - metabolism
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Zusammenfassung:Pathogenesis of progressive liver fibrosis in biliary atresia after successful portoenterostomy remains unclear. We related hepatic expression of transforming growth factor beta (TGF-β) superfamily cytokines to histologic liver injury after successful portoenterostomy. Enrolled in our study were 28 patients with biliary atresia who had liver biopsies obtained during and after successful portoenterostomy, which normalized serum bilirubin (
ISSN:0039-6060
1532-7361
DOI:10.1016/j.surg.2018.12.003