Expression of ELF1, a lymphoid ETS domain‐containing transcription factor, is recurrently lost in classical Hodgkin lymphoma

Summary Loss of B cell‐specific transcription factors (TFs) and the resulting loss of B‐cell phenotype of Hodgkin and Reed‐Sternberg (HRS) cells is a hallmark of classical Hodgkin lymphoma (cHL). Here we have analysed two members of ETS domain containing TFs, ELF1 and ELF2, regarding (epi)genomic ch...

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Veröffentlicht in:	British journal of haematology 2019-04, Vol.185 (1), p.79-88
Hauptverfasser:	Paczkowska, Julia, Soloch, Natalia, Bodnar, Magdalena, Kiwerska, Katarzyna, Janiszewska, Joanna, Vogt, Julia, Domanowska, Ewa, Martin‐Subero, José I., Ammerpohl, Ole, Klapper, Wolfram, Marszalek, Andrzej, Siebert, Reiner, Giefing, Maciej
Format:	Artikel
Sprache:	eng
Schlagworte:	B-Lymphocytes - metabolism B-Lymphocytes - pathology Biopsy Cell Line, Tumor classical Hodgkin lymphoma Deoxyribonucleic acid DNA DNA Methylation ELF1 ELF2 Epigenetics ETS Motif - genetics ETS protein Gene Deletion Hematology Heterozygote Hodgkin Disease - diagnosis Hodgkin Disease - genetics Hodgkin Disease - metabolism Hodgkin's lymphoma Humans Immunohistochemistry loss of B‐cell identity Lymphocytes B Lymphoma Mutation Nuclear Proteins - chemistry Nuclear Proteins - genetics Nuclear Proteins - metabolism Phenotypes Proteins RNA, Messenger - genetics RNA, Messenger - metabolism Transcription factors Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism
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Zusammenfassung:	Summary Loss of B cell‐specific transcription factors (TFs) and the resulting loss of B‐cell phenotype of Hodgkin and Reed‐Sternberg (HRS) cells is a hallmark of classical Hodgkin lymphoma (cHL). Here we have analysed two members of ETS domain containing TFs, ELF1 and ELF2, regarding (epi)genomic changes as well as gene and protein expression. We observed absence or lower levels of ELF1 protein in HRS cells of 31/35 (89%) cases compared to the bystander cells and significant (P
ISSN:	0007-1048 1365-2141
DOI:	10.1111/bjh.15757