Prognostic roles of time to positivity of blood culture in children with Streptococcus pneumoniae bacteremia
We aimed to investigate the relationship between time to positivity (TTP) of blood cultures and clinical outcomes in children with S. pneumoniae bacteremia. Children with S. pneumoniae bacteremia hospitalized in Children’s Hospital of Chongqing Medical University from May 2011 to December 2017 were...
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| Veröffentlicht in: | European journal of clinical microbiology & infectious diseases 2019-03, Vol.38 (3), p.457-465 |
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| container_title | European journal of clinical microbiology & infectious diseases |
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| creator | Li, Qinyuan Li, Yuanyuan Yi, Qian Suo, Fengtao Tang, Yuan Luo, Siying Tian, Xiaoyin Zhang, Guangli Chen, Dapeng Luo, Zhengxiu |
| description | We aimed to investigate the relationship between time to positivity (TTP) of blood cultures and clinical outcomes in children with
S. pneumoniae
bacteremia. Children with
S. pneumoniae
bacteremia hospitalized in Children’s Hospital of Chongqing Medical University from May 2011 to December 2017 were enrolled retrospectively. Overall, 136 children with
S. pneumoniae
bacteremia were enrolled. The standard cutoff TTP was 12 h. We stated that in-hospital mortality is significantly higher in the early TTP (≤ 12 h) group than that in the late TTP (> 12 h) group (41.70% vs 8.00%,
P
|
| doi_str_mv | 10.1007/s10096-018-03443-5 |
| format | Article |
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S. pneumoniae
bacteremia. Children with
S. pneumoniae
bacteremia hospitalized in Children’s Hospital of Chongqing Medical University from May 2011 to December 2017 were enrolled retrospectively. Overall, 136 children with
S. pneumoniae
bacteremia were enrolled. The standard cutoff TTP was 12 h. We stated that in-hospital mortality is significantly higher in the early TTP (≤ 12 h) group than that in the late TTP (> 12 h) group (41.70% vs 8.00%,
P
< 0.001). Septic shock occurred in 58.30% of patients with early TTP and in 21.00% of patients with late TTP (
P
< 0.001). Independent risk factors of in-hospital mortality and septic shock in children with
S. pneumoniae
bacteremia included early TTP, need for invasive mechanical ventilation, and PRISM III score ≥ 10. Overall, TTP ≤ 12 h appeared to associate with the worse outcomes for children with
S. pneumoniae
bacteremia.</description><identifier>ISSN: 0934-9723</identifier><identifier>EISSN: 1435-4373</identifier><identifier>DOI: 10.1007/s10096-018-03443-5</identifier><identifier>PMID: 30680552</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Bacteremia ; Biomedical and Life Sciences ; Biomedicine ; Blood ; Blood culture ; Children ; Internal Medicine ; Mechanical ventilation ; Medical Microbiology ; Mortality ; Original Article ; Patients ; Risk analysis ; Risk factors ; Sepsis ; Septic shock ; Streptococcus infections ; Streptococcus pneumoniae ; Ventilation</subject><ispartof>European journal of clinical microbiology & infectious diseases, 2019-03, Vol.38 (3), p.457-465</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>European Journal of Clinical Microbiology & Infectious Diseases is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-2c95574e36cbc8cd1523fb833320cf3544c6dbd3408ab5874ab592058503b1b03</citedby><cites>FETCH-LOGICAL-c375t-2c95574e36cbc8cd1523fb833320cf3544c6dbd3408ab5874ab592058503b1b03</cites><orcidid>0000-0003-3029-9624</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10096-018-03443-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10096-018-03443-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27928,27929,41492,42561,51323</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30680552$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Qinyuan</creatorcontrib><creatorcontrib>Li, Yuanyuan</creatorcontrib><creatorcontrib>Yi, Qian</creatorcontrib><creatorcontrib>Suo, Fengtao</creatorcontrib><creatorcontrib>Tang, Yuan</creatorcontrib><creatorcontrib>Luo, Siying</creatorcontrib><creatorcontrib>Tian, Xiaoyin</creatorcontrib><creatorcontrib>Zhang, Guangli</creatorcontrib><creatorcontrib>Chen, Dapeng</creatorcontrib><creatorcontrib>Luo, Zhengxiu</creatorcontrib><title>Prognostic roles of time to positivity of blood culture in children with Streptococcus pneumoniae bacteremia</title><title>European journal of clinical microbiology & infectious diseases</title><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><description>We aimed to investigate the relationship between time to positivity (TTP) of blood cultures and clinical outcomes in children with
S. pneumoniae
bacteremia. Children with
S. pneumoniae
bacteremia hospitalized in Children’s Hospital of Chongqing Medical University from May 2011 to December 2017 were enrolled retrospectively. Overall, 136 children with
S. pneumoniae
bacteremia were enrolled. The standard cutoff TTP was 12 h. We stated that in-hospital mortality is significantly higher in the early TTP (≤ 12 h) group than that in the late TTP (> 12 h) group (41.70% vs 8.00%,
P
< 0.001). Septic shock occurred in 58.30% of patients with early TTP and in 21.00% of patients with late TTP (
P
< 0.001). Independent risk factors of in-hospital mortality and septic shock in children with
S. pneumoniae
bacteremia included early TTP, need for invasive mechanical ventilation, and PRISM III score ≥ 10. Overall, TTP ≤ 12 h appeared to associate with the worse outcomes for children with
S. pneumoniae
bacteremia.</description><subject>Bacteremia</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood</subject><subject>Blood culture</subject><subject>Children</subject><subject>Internal Medicine</subject><subject>Mechanical ventilation</subject><subject>Medical Microbiology</subject><subject>Mortality</subject><subject>Original Article</subject><subject>Patients</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Sepsis</subject><subject>Septic shock</subject><subject>Streptococcus infections</subject><subject>Streptococcus pneumoniae</subject><subject>Ventilation</subject><issn>0934-9723</issn><issn>1435-4373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kUFvFSEUhYnR2Gf1D7gwJG7cTAUuDMyyaVpt0kQTdU0G5k5LMzNMgbHpv5fnqzZx4eaQwHfOveEQ8pazE86Y_pirdm3DuGkYSAmNekZ2XIJqJGh4TnasA9l0WsAReZXzLasmo_VLcgSsNUwpsSPT1xSvl5hL8DTFCTONIy1hRloiXWMOJfwM5WF_66YYB-q3qWwJaViovwnTkHCh96Hc0G8l4Vqij95vma4LbnNcQo_U9b5gwjn0r8mLsZ8yvnk8j8mPi_PvZ5-bqy-fLs9OrxoPWpVG-E4pLRFa77zxA1cCRmcAQDA_gpLSt4MbQDLTO2W0rNoJpoxi4LhjcEw-HHLXFO82zMXOIXucpn7BuGUruO6k5C2Dir7_B72NW1rqdnuK6U4AmEqJA-VTzDnhaNcU5j49WM7svgt76MLWLuzvLqyqpneP0Zubcfhr-fP5FYADkOvTco3pafZ_Yn8Bhj-U8g</recordid><startdate>20190301</startdate><enddate>20190301</enddate><creator>Li, Qinyuan</creator><creator>Li, Yuanyuan</creator><creator>Yi, Qian</creator><creator>Suo, Fengtao</creator><creator>Tang, Yuan</creator><creator>Luo, Siying</creator><creator>Tian, Xiaoyin</creator><creator>Zhang, Guangli</creator><creator>Chen, Dapeng</creator><creator>Luo, Zhengxiu</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3029-9624</orcidid></search><sort><creationdate>20190301</creationdate><title>Prognostic roles of time to positivity of blood culture in children with Streptococcus pneumoniae bacteremia</title><author>Li, Qinyuan ; Li, Yuanyuan ; Yi, Qian ; Suo, Fengtao ; Tang, Yuan ; Luo, Siying ; Tian, Xiaoyin ; Zhang, Guangli ; Chen, Dapeng ; Luo, Zhengxiu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-2c95574e36cbc8cd1523fb833320cf3544c6dbd3408ab5874ab592058503b1b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Bacteremia</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood</topic><topic>Blood culture</topic><topic>Children</topic><topic>Internal Medicine</topic><topic>Mechanical ventilation</topic><topic>Medical Microbiology</topic><topic>Mortality</topic><topic>Original Article</topic><topic>Patients</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Sepsis</topic><topic>Septic shock</topic><topic>Streptococcus infections</topic><topic>Streptococcus pneumoniae</topic><topic>Ventilation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Qinyuan</creatorcontrib><creatorcontrib>Li, Yuanyuan</creatorcontrib><creatorcontrib>Yi, Qian</creatorcontrib><creatorcontrib>Suo, Fengtao</creatorcontrib><creatorcontrib>Tang, Yuan</creatorcontrib><creatorcontrib>Luo, Siying</creatorcontrib><creatorcontrib>Tian, Xiaoyin</creatorcontrib><creatorcontrib>Zhang, Guangli</creatorcontrib><creatorcontrib>Chen, Dapeng</creatorcontrib><creatorcontrib>Luo, Zhengxiu</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>Proquest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical microbiology & infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Qinyuan</au><au>Li, Yuanyuan</au><au>Yi, Qian</au><au>Suo, Fengtao</au><au>Tang, Yuan</au><au>Luo, Siying</au><au>Tian, Xiaoyin</au><au>Zhang, Guangli</au><au>Chen, Dapeng</au><au>Luo, Zhengxiu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic roles of time to positivity of blood culture in children with Streptococcus pneumoniae bacteremia</atitle><jtitle>European journal of clinical microbiology & infectious diseases</jtitle><stitle>Eur J Clin Microbiol Infect Dis</stitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><date>2019-03-01</date><risdate>2019</risdate><volume>38</volume><issue>3</issue><spage>457</spage><epage>465</epage><pages>457-465</pages><issn>0934-9723</issn><eissn>1435-4373</eissn><abstract>We aimed to investigate the relationship between time to positivity (TTP) of blood cultures and clinical outcomes in children with
S. pneumoniae
bacteremia. Children with
S. pneumoniae
bacteremia hospitalized in Children’s Hospital of Chongqing Medical University from May 2011 to December 2017 were enrolled retrospectively. Overall, 136 children with
S. pneumoniae
bacteremia were enrolled. The standard cutoff TTP was 12 h. We stated that in-hospital mortality is significantly higher in the early TTP (≤ 12 h) group than that in the late TTP (> 12 h) group (41.70% vs 8.00%,
P
< 0.001). Septic shock occurred in 58.30% of patients with early TTP and in 21.00% of patients with late TTP (
P
< 0.001). Independent risk factors of in-hospital mortality and septic shock in children with
S. pneumoniae
bacteremia included early TTP, need for invasive mechanical ventilation, and PRISM III score ≥ 10. Overall, TTP ≤ 12 h appeared to associate with the worse outcomes for children with
S. pneumoniae
bacteremia.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>30680552</pmid><doi>10.1007/s10096-018-03443-5</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-3029-9624</orcidid></addata></record> |
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| language | eng |
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| source | SpringerNature Journals |
| subjects | Bacteremia Biomedical and Life Sciences Biomedicine Blood Blood culture Children Internal Medicine Mechanical ventilation Medical Microbiology Mortality Original Article Patients Risk analysis Risk factors Sepsis Septic shock Streptococcus infections Streptococcus pneumoniae Ventilation |
| title | Prognostic roles of time to positivity of blood culture in children with Streptococcus pneumoniae bacteremia |
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