Pseudogene repair driven by selection pressure applied in experimental evolution

Pseudogenes represent open reading frames that have been damaged by mutations, rendering the gene product non-functional. Pseudogenes are found in many genomes and are not always eliminated, even if they are potentially 'wasteful'. This raises a fundamental question about their prevalence....

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Veröffentlicht in:Nature microbiology 2019-03, Vol.4 (3), p.386-389
Hauptverfasser: Anand, Amitesh, Olson, Connor A, Yang, Laurence, Sastry, Anand V, Catoiu, Edward, Choudhary, Kumari Sonal, Phaneuf, Patrick V, Sandberg, Troy E, Xu, Sibei, Hefner, Ying, Szubin, Richard, Feist, Adam M, Palsson, Bernhard O
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Sprache:eng
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Zusammenfassung:Pseudogenes represent open reading frames that have been damaged by mutations, rendering the gene product non-functional. Pseudogenes are found in many genomes and are not always eliminated, even if they are potentially 'wasteful'. This raises a fundamental question about their prevalence. Here we report pseudogene efeU repair that restores the iron uptake system of Escherichia coli under a designed selection pressure during adaptive laboratory evolution.
ISSN:2058-5276
2058-5276
DOI:10.1038/s41564-018-0340-2