The impact of chemotherapy on survival of patients with extremity and trunk wall soft tissue sarcoma: revisiting the results of the EORTC-STBSG 62931 randomised trial

This study was aimed at determining whether patients with high-risk soft tissue sarcoma (STS), as identified using the nomogram Sarculator, benefitted from adjuvant chemotherapy in the EORTC-STBSG 62931 randomised controlled trial (RCT), which failed to detect an impact for adjuvant doxorubicin plus...

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Veröffentlicht in:	European journal of cancer (1990) 2019-03, Vol.109, p.51-60
Hauptverfasser:	Pasquali, Sandro, Pizzamiglio, Sara, Touati, Nathan, Litiere, Saskia, Marreaud, Sandrine, Kasper, Bernd, Gelderblom, Hans, Stacchiotti, Silvia, Judson, Ian, Dei Tos, Angelo P., Verderio, Paolo, Casali, Paolo G., Woll, Penella J., Gronchi, Alessandro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant Adolescent Adult Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Chemotherapy Chemotherapy, Adjuvant - mortality Confidence intervals Doxorubicin Doxorubicin - administration & dosage Extremities - pathology Female Follow-Up Studies High risk Humans Ifosfamide Ifosfamide - administration & dosage Male Mathematical analysis Middle Aged Neoadjuvant Therapy - mortality Nomograms Overall survival Patients Prognosis Randomised controlled trial Randomization Rank tests Risk Risk groups Sarcoma Sarcoma - drug therapy Sarcoma - mortality Sarcoma - pathology Soft tissue sarcoma Soft tissues Statistical analysis Survival Survival Rate Tissues Torso - pathology Young Adult
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Zusammenfassung:	This study was aimed at determining whether patients with high-risk soft tissue sarcoma (STS), as identified using the nomogram Sarculator, benefitted from adjuvant chemotherapy in the EORTC-STBSG 62931 randomised controlled trial (RCT), which failed to detect an impact for adjuvant doxorubicin plus ifosfamide (Adj) over observation (Obs). Patients with extremity and trunk wall STS in the EORTC-STBSG 62931 RCT were analysed (N = 290/351). Ten-year predicted probability of overall survival (pr-OS) was calculated using the prognostic nomogram Sarculator. Patients were grouped into three categories of predicted pr-OS: high (pr-OS>66%), intermediate (51
ISSN:	0959-8049 1879-0852
DOI:	10.1016/j.ejca.2018.12.009