γδ TCR ligands: the quest to solve a 500-million-year-old mystery

γδ T cells have been retained as a lineage over the majority of vertebrate evolution, are able to respond to immune challenges in unique ways, and are of increasing therapeutic interest. However, one central mystery has endured: the identity of the ligands recognized by the γδ T cell antigen recepto...

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Veröffentlicht in:	Nature immunology 2019-02, Vol.20 (2), p.121-128
Hauptverfasser:	Willcox, Benjamin E., Willcox, Carrie R.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/1619/554/1775 631/250/1619/554/2509 Animals Biomedical and Life Sciences Biomedicine Cell Differentiation - immunology Cell Lineage - immunology Humans Immunology Infectious Diseases Ligands Lymphocytes Lymphocytes T Perspective Receptors, Antigen, T-Cell, gamma-delta - immunology Receptors, Antigen, T-Cell, gamma-delta - metabolism Signal Transduction - immunology T cell receptors T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism Vertebrates
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Beschreibung
Zusammenfassung:	γδ T cells have been retained as a lineage over the majority of vertebrate evolution, are able to respond to immune challenges in unique ways, and are of increasing therapeutic interest. However, one central mystery has endured: the identity of the ligands recognized by the γδ T cell antigen receptor. Here we discuss the inherent challenges in answering this question, the new opportunities provided by recent studies, and the criteria by which the field might judge success. In this Perspective, Willcox and Willcox discuss the inherent challenges and future possibilities in identifying the ligands recognized by the γδ TCR.
ISSN:	1529-2908 1529-2916
DOI:	10.1038/s41590-018-0304-y