New developments on interferon-γ release assays for tuberculosis diagnosis

New developments on interferon-γ release assays for tuberculosis diagnosis

[...]generation IGRAs were developed from TSPOT.TB with additional antigen Rv3615c, or without ESAT-6 but including Rv3615c and Rv3879c. [...]indeterminate test results, possibly reflecting an impaired immune status, and borderline results were excluded from the analysis, as were data from participa...

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Veröffentlicht in:The Lancet infectious diseases 2019-02, Vol.19 (2), p.121-122
Hauptverfasser: Arend, Sandra M, Uzorka, Jonathan W
Format: Artikel
Sprache:eng
Schlagworte:
Antigens
Cohort Studies
Data processing
ESAT-6 antigen
HIV
Human immunodeficiency virus
Humans
Immune status
Infectious diseases
Interferon
Interferon-gamma Release Tests
Medical diagnosis
Tuberculin Test
Tuberculosis
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Zusammenfassung:[...]generation IGRAs were developed from TSPOT.TB with additional antigen Rv3615c, or without ESAT-6 but including Rv3615c and Rv3879c. [...]indeterminate test results, possibly reflecting an impaired immune status, and borderline results were excluded from the analysis, as were data from participants in the clinically indeterminate category. [...]indeterminate results were frequent and the sensitivity of second-generation IGRAs was low (70·6%) among HIV-infected patients.
ISSN:1473-3099
1474-4457
DOI:10.1016/S1473-3099(18)30651-0