Pediatric Human Immunodeficiency Virus and Otolaryngologic Manifestations: An Analysis of Hospital Admissions From 1997 to 2012
Objectives/Hypothesis Many human immunodeficiency virus (HIV)–infected pediatric patients develop otolaryngologic disease. We aimed to characterize their otolaryngologic manifestations by type and demographic variation, and model temporal trends. Study Design Retrospective cohort review. Methods A r...
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| Veröffentlicht in: | The Laryngoscope 2019-11, Vol.129 (11), p.E377-E382 |
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| container_title | The Laryngoscope |
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| creator | Govindan, Aparna Zhu, Yan Azmy, Monica C. Lee, Yung‐Jae Kalyoussef, Evelyne |
| description | Objectives/Hypothesis
Many human immunodeficiency virus (HIV)–infected pediatric patients develop otolaryngologic disease. We aimed to characterize their otolaryngologic manifestations by type and demographic variation, and model temporal trends.
Study Design
Retrospective cohort review.
Methods
A retrospective review utilizing the Kids’ Inpatient Database (KID) was conducted. International Classification of Diseases, Ninth Revision, Clinical Modification codes for HIV and otolaryngologic diagnoses were used to query data from the triennially published KID files from 1997 to 2012. A subset analysis of infectious versus non‐infectious admitting otolaryngologic diagnoses was conducted.
Results
A total of 11,150 cases met the inclusion criteria. Of these cases, 21.8% were admitted for otolaryngologic manifestations, with 18.0% presenting with infectious symptomatology, 4.8% with noninfectious disease, and 1.0% with both. On average, patients presenting with infectious disease were younger (8.17 years vs. 9.65 years, P < .001). Patients in the South were significantly more likely to be admitted for infection (54.8% vs. 42.0%, P < .001), with non‐infectious predominance in the Northeast and West. HIV‐infected children in 1997 were more likely to present with infectious otolaryngologic disease (56.3% vs. 45.8%, P < .001); however, there has been a decrease in the prevalence of infectious head and neck presentations (46.5%, 19.9%, 11.5%, 6.7%, 3.7%, and 1.9% from 1997 to 2012), and a gradual shift toward noninfectious manifestation with notable differences in 2000 and 2012 (19.9% vs. 25.2%; P = .017; and 1.9% vs. 4.8%, P < .001, respectively).
Conclusions
Otolaryngologic disease accounts for nearly one‐fifth of hospitalizations in HIV‐infected children; however, rates of hospitalization as well as otolaryngologic manifestations have progressively decreased over time. HIV‐infected children nowadays are more likely to present with noninfectious rather than infectious disease.
Level of Evidence
NA Laryngoscope, 129:E377–E382, 2019 |
| doi_str_mv | 10.1002/lary.27778 |
| format | Article |
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Many human immunodeficiency virus (HIV)–infected pediatric patients develop otolaryngologic disease. We aimed to characterize their otolaryngologic manifestations by type and demographic variation, and model temporal trends.
Study Design
Retrospective cohort review.
Methods
A retrospective review utilizing the Kids’ Inpatient Database (KID) was conducted. International Classification of Diseases, Ninth Revision, Clinical Modification codes for HIV and otolaryngologic diagnoses were used to query data from the triennially published KID files from 1997 to 2012. A subset analysis of infectious versus non‐infectious admitting otolaryngologic diagnoses was conducted.
Results
A total of 11,150 cases met the inclusion criteria. Of these cases, 21.8% were admitted for otolaryngologic manifestations, with 18.0% presenting with infectious symptomatology, 4.8% with noninfectious disease, and 1.0% with both. On average, patients presenting with infectious disease were younger (8.17 years vs. 9.65 years, P < .001). Patients in the South were significantly more likely to be admitted for infection (54.8% vs. 42.0%, P < .001), with non‐infectious predominance in the Northeast and West. HIV‐infected children in 1997 were more likely to present with infectious otolaryngologic disease (56.3% vs. 45.8%, P < .001); however, there has been a decrease in the prevalence of infectious head and neck presentations (46.5%, 19.9%, 11.5%, 6.7%, 3.7%, and 1.9% from 1997 to 2012), and a gradual shift toward noninfectious manifestation with notable differences in 2000 and 2012 (19.9% vs. 25.2%; P = .017; and 1.9% vs. 4.8%, P < .001, respectively).
Conclusions
Otolaryngologic disease accounts for nearly one‐fifth of hospitalizations in HIV‐infected children; however, rates of hospitalization as well as otolaryngologic manifestations have progressively decreased over time. HIV‐infected children nowadays are more likely to present with noninfectious rather than infectious disease.
Level of Evidence
NA Laryngoscope, 129:E377–E382, 2019</description><identifier>ISSN: 0023-852X</identifier><identifier>EISSN: 1531-4995</identifier><identifier>DOI: 10.1002/lary.27778</identifier><identifier>PMID: 30667060</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Child ; Databases, Factual ; Female ; HIV ; HIV Infections - complications ; HIV Infections - virology ; Hospitalization - statistics & numerical data ; Human immunodeficiency virus ; Humans ; infectious ; Infectious diseases ; Kids’ Inpatient Database (KID) ; Male ; Otolaryngology ; Otorhinolaryngologic Diseases - epidemiology ; Otorhinolaryngologic Diseases - virology ; Pediatrics ; Prevalence ; Retrospective Studies ; United States - epidemiology</subject><ispartof>The Laryngoscope, 2019-11, Vol.129 (11), p.E377-E382</ispartof><rights>2019 The American Laryngological, Rhinological and Otological Society, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3578-6575ce3d52c185744a015a5819ade4703fad4e696844c85072013332fd684ee13</citedby><cites>FETCH-LOGICAL-c3578-6575ce3d52c185744a015a5819ade4703fad4e696844c85072013332fd684ee13</cites><orcidid>0000-0002-4041-2371 ; 0000-0002-1016-0070</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Flary.27778$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Flary.27778$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30667060$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Govindan, Aparna</creatorcontrib><creatorcontrib>Zhu, Yan</creatorcontrib><creatorcontrib>Azmy, Monica C.</creatorcontrib><creatorcontrib>Lee, Yung‐Jae</creatorcontrib><creatorcontrib>Kalyoussef, Evelyne</creatorcontrib><title>Pediatric Human Immunodeficiency Virus and Otolaryngologic Manifestations: An Analysis of Hospital Admissions From 1997 to 2012</title><title>The Laryngoscope</title><addtitle>Laryngoscope</addtitle><description>Objectives/Hypothesis
Many human immunodeficiency virus (HIV)–infected pediatric patients develop otolaryngologic disease. We aimed to characterize their otolaryngologic manifestations by type and demographic variation, and model temporal trends.
Study Design
Retrospective cohort review.
Methods
A retrospective review utilizing the Kids’ Inpatient Database (KID) was conducted. International Classification of Diseases, Ninth Revision, Clinical Modification codes for HIV and otolaryngologic diagnoses were used to query data from the triennially published KID files from 1997 to 2012. A subset analysis of infectious versus non‐infectious admitting otolaryngologic diagnoses was conducted.
Results
A total of 11,150 cases met the inclusion criteria. Of these cases, 21.8% were admitted for otolaryngologic manifestations, with 18.0% presenting with infectious symptomatology, 4.8% with noninfectious disease, and 1.0% with both. On average, patients presenting with infectious disease were younger (8.17 years vs. 9.65 years, P < .001). Patients in the South were significantly more likely to be admitted for infection (54.8% vs. 42.0%, P < .001), with non‐infectious predominance in the Northeast and West. HIV‐infected children in 1997 were more likely to present with infectious otolaryngologic disease (56.3% vs. 45.8%, P < .001); however, there has been a decrease in the prevalence of infectious head and neck presentations (46.5%, 19.9%, 11.5%, 6.7%, 3.7%, and 1.9% from 1997 to 2012), and a gradual shift toward noninfectious manifestation with notable differences in 2000 and 2012 (19.9% vs. 25.2%; P = .017; and 1.9% vs. 4.8%, P < .001, respectively).
Conclusions
Otolaryngologic disease accounts for nearly one‐fifth of hospitalizations in HIV‐infected children; however, rates of hospitalization as well as otolaryngologic manifestations have progressively decreased over time. HIV‐infected children nowadays are more likely to present with noninfectious rather than infectious disease.
Level of Evidence
NA Laryngoscope, 129:E377–E382, 2019</description><subject>Child</subject><subject>Databases, Factual</subject><subject>Female</subject><subject>HIV</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - virology</subject><subject>Hospitalization - statistics & numerical data</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>infectious</subject><subject>Infectious diseases</subject><subject>Kids’ Inpatient Database (KID)</subject><subject>Male</subject><subject>Otolaryngology</subject><subject>Otorhinolaryngologic Diseases - epidemiology</subject><subject>Otorhinolaryngologic Diseases - virology</subject><subject>Pediatrics</subject><subject>Prevalence</subject><subject>Retrospective Studies</subject><subject>United States - epidemiology</subject><issn>0023-852X</issn><issn>1531-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9LHDEYh0NR6mp78QNIoBcRRt_8m2S8LaJdYcVStLSnISYZicwkazJD2ZNfvdmu9dCDEAgkT573zftD6JDAKQGgZ71O61MqpVQf0IwIRireNGIHzcolq5SgP_fQfs5PAEQyAR_RHoO6llDDDL18c9brMXmDF9OgA74ehilE6zpvvAtmjX_4NGWsg8W3Y9yUCo-xj4_lwY0OvnN51KOPIZ_jeShL9-vsM44dXsS88qPu8dwOPucNg69SHDBpGonHiCkQ-gntdrrP7vPrfoDury7vLhbV8vbr9cV8WRkmpKpqIYVxzApqiBKScw1EaKFIo63jElinLXd1UyvOjRIgi5sxRjtbTpwj7AAdb72rFJ-n0nRbejKu73VwccotJbLhtAbeFPTLf-hTnFL5WKEYSCKJUlCoky1lUsw5ua5dJT-U8bQE2k0s7WZW7d9YCnz0qpweBmff0H85FIBsgd--d-t3VO1y_v3XVvoHgLWWbQ</recordid><startdate>201911</startdate><enddate>201911</enddate><creator>Govindan, Aparna</creator><creator>Zhu, Yan</creator><creator>Azmy, Monica C.</creator><creator>Lee, Yung‐Jae</creator><creator>Kalyoussef, Evelyne</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4041-2371</orcidid><orcidid>https://orcid.org/0000-0002-1016-0070</orcidid></search><sort><creationdate>201911</creationdate><title>Pediatric Human Immunodeficiency Virus and Otolaryngologic Manifestations: An Analysis of Hospital Admissions From 1997 to 2012</title><author>Govindan, Aparna ; Zhu, Yan ; Azmy, Monica C. ; Lee, Yung‐Jae ; Kalyoussef, Evelyne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3578-6575ce3d52c185744a015a5819ade4703fad4e696844c85072013332fd684ee13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Child</topic><topic>Databases, Factual</topic><topic>Female</topic><topic>HIV</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - virology</topic><topic>Hospitalization - statistics & numerical data</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>infectious</topic><topic>Infectious diseases</topic><topic>Kids’ Inpatient Database (KID)</topic><topic>Male</topic><topic>Otolaryngology</topic><topic>Otorhinolaryngologic Diseases - epidemiology</topic><topic>Otorhinolaryngologic Diseases - virology</topic><topic>Pediatrics</topic><topic>Prevalence</topic><topic>Retrospective Studies</topic><topic>United States - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Govindan, Aparna</creatorcontrib><creatorcontrib>Zhu, Yan</creatorcontrib><creatorcontrib>Azmy, Monica C.</creatorcontrib><creatorcontrib>Lee, Yung‐Jae</creatorcontrib><creatorcontrib>Kalyoussef, Evelyne</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The Laryngoscope</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Govindan, Aparna</au><au>Zhu, Yan</au><au>Azmy, Monica C.</au><au>Lee, Yung‐Jae</au><au>Kalyoussef, Evelyne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pediatric Human Immunodeficiency Virus and Otolaryngologic Manifestations: An Analysis of Hospital Admissions From 1997 to 2012</atitle><jtitle>The Laryngoscope</jtitle><addtitle>Laryngoscope</addtitle><date>2019-11</date><risdate>2019</risdate><volume>129</volume><issue>11</issue><spage>E377</spage><epage>E382</epage><pages>E377-E382</pages><issn>0023-852X</issn><eissn>1531-4995</eissn><abstract>Objectives/Hypothesis
Many human immunodeficiency virus (HIV)–infected pediatric patients develop otolaryngologic disease. We aimed to characterize their otolaryngologic manifestations by type and demographic variation, and model temporal trends.
Study Design
Retrospective cohort review.
Methods
A retrospective review utilizing the Kids’ Inpatient Database (KID) was conducted. International Classification of Diseases, Ninth Revision, Clinical Modification codes for HIV and otolaryngologic diagnoses were used to query data from the triennially published KID files from 1997 to 2012. A subset analysis of infectious versus non‐infectious admitting otolaryngologic diagnoses was conducted.
Results
A total of 11,150 cases met the inclusion criteria. Of these cases, 21.8% were admitted for otolaryngologic manifestations, with 18.0% presenting with infectious symptomatology, 4.8% with noninfectious disease, and 1.0% with both. On average, patients presenting with infectious disease were younger (8.17 years vs. 9.65 years, P < .001). Patients in the South were significantly more likely to be admitted for infection (54.8% vs. 42.0%, P < .001), with non‐infectious predominance in the Northeast and West. HIV‐infected children in 1997 were more likely to present with infectious otolaryngologic disease (56.3% vs. 45.8%, P < .001); however, there has been a decrease in the prevalence of infectious head and neck presentations (46.5%, 19.9%, 11.5%, 6.7%, 3.7%, and 1.9% from 1997 to 2012), and a gradual shift toward noninfectious manifestation with notable differences in 2000 and 2012 (19.9% vs. 25.2%; P = .017; and 1.9% vs. 4.8%, P < .001, respectively).
Conclusions
Otolaryngologic disease accounts for nearly one‐fifth of hospitalizations in HIV‐infected children; however, rates of hospitalization as well as otolaryngologic manifestations have progressively decreased over time. HIV‐infected children nowadays are more likely to present with noninfectious rather than infectious disease.
Level of Evidence
NA Laryngoscope, 129:E377–E382, 2019</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>30667060</pmid><doi>10.1002/lary.27778</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-4041-2371</orcidid><orcidid>https://orcid.org/0000-0002-1016-0070</orcidid></addata></record> |
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| subjects | Child Databases, Factual Female HIV HIV Infections - complications HIV Infections - virology Hospitalization - statistics & numerical data Human immunodeficiency virus Humans infectious Infectious diseases Kids’ Inpatient Database (KID) Male Otolaryngology Otorhinolaryngologic Diseases - epidemiology Otorhinolaryngologic Diseases - virology Pediatrics Prevalence Retrospective Studies United States - epidemiology |
| title | Pediatric Human Immunodeficiency Virus and Otolaryngologic Manifestations: An Analysis of Hospital Admissions From 1997 to 2012 |
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