Receptor Structures for a Caldron of Cannabinoids

Receptor Structures for a Caldron of Cannabinoids

Structures of the cannabinoid receptor 1 (CB1) in complex with an “ultrapotent” synthetic cannabinoid and its G protein (Krishna Kumar et al., 2019) and CB2 in complex with a new rationally designed inverse agonist (Li et al., 2019) provide unique snapshots of the molecular pharmacology of cannabino...

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Veröffentlicht in:Cell 2019-01, Vol.176 (3), p.409-411
Hauptverfasser: Lorenzen, Emily, Sakmar, Thomas P.
Format: Artikel
Sprache:eng
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Zusammenfassung:Structures of the cannabinoid receptor 1 (CB1) in complex with an “ultrapotent” synthetic cannabinoid and its G protein (Krishna Kumar et al., 2019) and CB2 in complex with a new rationally designed inverse agonist (Li et al., 2019) provide unique snapshots of the molecular pharmacology of cannabinoids. Structures of the cannabinoid receptor 1 (CB1) in complex with an “ultrapotent” synthetic cannabinoid and its G protein (Krishna Kumar et al., 2019) and CB2 in complex with a new rationally designed inverse agonist (Li et al., 2019) provide unique snapshots of the molecular pharmacology of cannabinoids.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2019.01.012